Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI.

The pulmonary and systemic availability of budesonide after inhalation from a dry powder inhaler, Turbuhaler, and from a pressurized metered-dose inhaler (P-MDI) were compared in healthy volunteers. Two different methods were used to assess pulmonary availability: 1) calculated from the systemic availability corrected for an oral availability of 13% (n = 24); and 2) after blocking of gastrointestinal absorption by administration of a charcoal suspension (n = 13). An intravenous infusion of budesonide was used as a reference.

Cancer risk in asthmatic subjects selected from hospital discharge registry.

We wanted to study cancer risk in asthmatic subjects. With the use of central health registries, a cohort of 64,346 patients, treated in hospital with an asthma diagnosis, was followed with respect to cancer development. The observed numbers of different types of cancer were compared with the expected numbers, estimated from population data, with consideration taken to patient age, sex, survival, and the year of diagnosis.

Intravenous infusion of enprofylline with an exponentially decreasing drug concentration in acute asthma.

Nine patients (3 women), aged 29-78 years, with acute asthma were treated with the antiasthma xanthine, enprofylline, in an open-design study without a reference drug. Enprofylline was administered intravenously (i.v.

Comparison of neurokinin A and substance P on cardiovascular and airway function in man.

The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion.

Reproducibility of heart rate changes following adenosine infusion in man.

The change in heart rate following infusion of adenosine in healthy human subjects was studied on two occasions. Adenosine produced a significant, dose-related increase in heart rate. Tachyphylaxis to this effect of the naturally occurring nucleoside did not occur.