[Ibuprofen: safety and efficiency of its use in wide clinical practice].

The paper presents data on the pharmacokinetics of the nonsteroidal anti-inflammatory drug ibuprofen and a review of the evidence base that suggests its clinical efficacy and safety in different categories of patients and discusses new, potentially possible indications for the use of this drug. Ibuprofen has marked anti-inflammatory, analgesic, and antipyretic effects, which along with its good tolerability, predictability of side effects, and a low risk of complications, allows it to be widely use in clinical practice. There are various ibuprofen formulations on the drug market.

[An experience of the use of a fixed atenolol amlodipine combination in real clinical practice: results of multicenter Russian study].

Aim: To assess clinical, hemodynamic efficacy and tolerability of a Fixed Atenolol Amlodipine Combination (FAAC) in patients with arterial 1-3 degree arterial hypertension as mono- or combination therapy.

Material And Methods: Antihypertensive efficacy and tolerability of FAAC was investigated in open noncomparative study in 22 centers in 17 cities of Russia on 570 patients (246 men, 324 women) aged 18-65 years (mean 55,53+8,55 years) with 1-3 degree arterial hypertension. Methods of control included office blood pressure (BP) measurement, 24-hour BP monitoring, electrocardiography, control of biochemical parameters, assessment of efficacy and tolerability.

[The effect of the new angiotensin-converting enzyme inhibitor moexipril on the circadian rhythms of arterial pressure in hypertension patients].

24-hour monitoring of arterial pressure was performed before, 3 and 9 weeks after moexipril treatment (daily dose 7.5-15 mg) for mild and moderate hypertension. Of 15 patients treated 66.