Publications by authors named "T Atwater"
Article Synopsis
- - Lung adenocarcinoma (LUAD) is a common and aggressive form of lung cancer, with its recurrence risk poorly understood, leading researchers to explore the role of immune response in tumor growth as a factor affecting patient outcomes.
- - The study analyzed immune cell density in tumors from 100 LUAD patients (stages I and II), using advanced techniques to assess T-cell and mast cell presence in relation to recurrence-free survival (RFS).
- - Findings indicate that higher densities of T-cells and mast cells in tumors are associated with significantly reduced recurrence risk, emphasizing the potential role of the immune environment in cancer prognosis, though further research is needed due to the small sample size.
Article Synopsis
- Myocardial oxygen delivery is controlled by changes in blood vessel tone to meet the heart's metabolic needs, with a focus on how this is affected by altitude and exercise.
- The study examined how the body's response to muscle metaboreflex activation during handgrip exercises differs between low altitude and both acute and prolonged high altitude conditions (3,800 m) in healthy males.
- Results showed that acute high altitude led to a significant reduction in blood flow and vascular conductance in the coronary arteries compared to low altitude, but these effects were normalized after 8-9 days at high altitude.
Article Synopsis
- The study investigates how coronary blood flow regulation during acute hypoxia and adrenergic activation differs between males and females.
- Both sexes show increased coronary blood velocity with hypoxia, but males' response is limited by adrenergic activity, while females are not affected in the same way.
- Findings highlight significant sex-based differences in coronary blood flow control, which could have implications for understanding cardiovascular responses in men and women.
Integrated Biomarkers for the Management of Indeterminate Pulmonary Nodules.
Am J Respir Crit Care Med
December 2021
Patients with indeterminate pulmonary nodules (IPNs) at risk of cancer undergo high rates of invasive, costly, and morbid procedures. To train and externally validate a risk prediction model that combined clinical, blood, and imaging biomarkers to improve the noninvasive management of IPNs. In this prospectively collected, retrospective blinded evaluation study, probability of cancer was calculated for 456 patient nodules using the Mayo Clinic model, and patients were categorized into low-, intermediate-, and high-risk groups.
View Article and Find Full Text PDFThe noninvasive diagnosis of lung cancer remains a formidable challenge. Although tissue diagnosis will remain the gold standard for the foreseeable future, questions pertaining to the risks and costs associated with invasive diagnostic procedures are of prime relevance. This review addresses new modalities for improving the noninvasive evaluation of suspicious lung nodules.
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