Cationic Micelle-like Nanoparticles as the Carrier of Methotrexate for Glioblastoma Treatment.

In the present study, ultra-small, magnetic, oleyl amine-coated FeO nanoparticles were synthesized and stabilized with a cationic ligand, cetyltrimethylammonium bromide, and an anticancer drug, methotrexate, was incorporated into a micelle-like nanoparticle structure for glioblastoma treatment. Nanoparticles were further characterized for their physicochemical properties using spectroscopic methods. Drug incorporation efficiency, drug loading, and drug release profile of the nanoparticles were investigated.

Stress distribution in restored mandibular molars with external cervical resorption: a finite element analysis.

This study evaluates the stress distribution in mandibular molar teeth with external cervical resorption restored using various restorative and biomimetic materials through finite element analysis. A mandibular first molar was scanned to create a 3D model. 'Class 2Bp' external cervical resorption defects were simulated on the buccal aspect and restored with different materials.

Changes in physical activity among adults in Türkiye.

Background: Physical inactivity is a significant public health problem and a contributor to noncommunicable disease and worsening health status. It causes morbidity and an estimated 6-10% of premature deaths globally.

Aim: To investigate changes in physical activity among adults in Türkiye between 2014 and 2023 and the factors that influenced the changes.

Comparative analysis of cognitive and physical characteristics in late-onset, adult-onset and early-onset multiple sclerosis patients.

Background: Late-onset multiple sclerosis (LOMS or L; MS) and early-onset MS (EOMS or E) are less common, and their prognosis can be different. To characterize the demographic and clinical features, and clinical outcomes of LOMS and EOMS patients, comparing them to adult-onset MS (AOMS or A) patients.

Methods: The study was conducted as a secondary analysis of a prospective study.

The relationship between work difficulties and physical disability, cognitive and social cognitive impairment and subcortical gray matter atrophy in persons with multiple sclerosis.

Background: Multiple sclerosis (MS) is commonly associated with work difficulties. This study aimed to examine the relationship between work difficulties and physical disability, cognitive and social cognitive impairment, and subcortical gray matter (scGM) atrophy in pwMS.

Methods: Thirty-three employees with MS underwent assessments with Multiple Sclerosis Work Difficulties Questionnaire-23 MSWDQ-23.