Publications by authors named "T Arita"
Trastuzumab deruxtecan (T-DXd), an anti-HER2 antibody-drug conjugate with a topoisomerase I inhibitor connected by a cleavable linker, has been approved for patients with HER2-positive gastric or gastroesophageal junction tumors. This biomarker study assessed HER2 expression and immune cell infiltration in relation to the therapeutic response to T-DXd. This retrospective analysis included samples from patients treated with T-DXd in three clinical trials.
View Article and Find Full Text PDFRapid and Safe Neutralization Assay for Circulating H5N1 Influenza Virus in Dairy Cows.
Influenza Other Respir Viruses
December 2024
Rapid and safe neutralization assays are required for highly pathogenic avian influenza viruses, including a clade 2.3.4.
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- A study explored the potential for shorter oxaliplatin adjuvant chemotherapy for patients with high-risk stage II and low-risk stage III colon cancer, analyzing recurrence risks in 396 surgical patients.
- The findings showed that patients in the low-risk group had a better 3-year relapse-free survival rate, but those with high preoperative serum carcinoembryonic antigen (CEA) levels who didn't complete their treatment had poorer outcomes.
- The study concluded that patients in the low-risk group with elevated CEA levels should not reduce their chemotherapy duration, as it negatively affects their prognosis.
Background: Postoperative neurogenic bladder (PONB) frequently occurs as a complication after rectal cancer surgery. This study aimed to analyze risk factors for developing PONB after rectal cancer surgery, particularly the association between pelvic anatomy and visceral fat mass.
Methods: We included 138 patients who underwent rectal resection for lower rectal cancer in our department between 2017 and 2021.
Article Synopsis
- The glycocalyx (GCX) is a cellular surface layer linked to cancer, specifically its growth and spread, with glypican-1 (GPC1) being a key protein in this process for esophageal squamous cell carcinoma (ESCC).
- A study measured GPC1 levels in the plasma of advanced esophageal cancer patients and found high GPC1 levels correlated with worse clinical outcomes and significant cancer characteristics, such as tumor size and metastasis.
- The findings suggest that extracellular GPC1 can be a less invasive biomarker for monitoring ESCC progression and might serve as a potential target for new treatments.