Publications by authors named "T Andou"
Aims: Dipeptidyl peptidase-4 inhibitors (DPP4i) enhance GABAergic transmission via the glucagon-like peptide-1 (GLP-1)/GLP-1 receptor pathway. Oral γ-aminobutyric acid (GABA) administration reduces body temperature in humans; thus, DPP4i may reduce body temperature in humans. Therefore, this study aimed to determine the effects of DPP4i administration on the body temperature of patients with type 2 diabetes (T2D).
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- The study used Proximity Extension Assay (PEA) and mass spectrometry (MS) to analyze plasma samples from Alzheimer's disease patients, identifying 150 significantly variable proteins and 68 lipids from a larger pool of 1000 proteins and 400 lipids.
- The findings indicated a link between vascular fragility and Alzheimer's disease, with pathway analysis revealing that certain lipid-associated proteins and fatty acids could impact cardiovascular risk, suggesting a complex relationship between lipid metabolism and vascular health.
- The research highlights subtle homeostatic imbalances in vascular endothelial cells that may contribute to the chronic progression of Alzheimer's disease, underscored by the potential damaging effects of specific bile acids.
A simple bone cyst (SBC) in the posterior lumbar bone structure is very rare. Here, we report a case of SBC at the L5 lumbar lamina with venous obstruction associated with ligamentum flavum thickening. A 59-year-old woman presented with intermittent claudication due to low back pain and bilateral sciatica.
View Article and Find Full Text PDFValidation of biomarker assays is crucial for effective drug development and clinical applications. Interlaboratory reproducibility is vital for reliable comparison and combination of data from different centers. This review summarizes interlaboratory studies of quantitative LC-MS-based biomarker assays using reference standards for calibration curves.
View Article and Find Full Text PDFAims: Sodium load increases endogenous glucagon-like peptide-1 (GLP-1) levels in humans. Therefore, patients with an increased amount of dietary sodium intake are supposed to have higher endogenous GLP-1 levels compared to those with less dietary sodium intake. Therefore, it can be hypothesized that patients with type 2 diabetes mellitus (T2DM) with more dietary sodium intake show better dipeptidyl peptidase-4 inhibitor (DPP-4i) effect on glycemic control because of the expected higher GLP-1 level.
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