Publications by authors named "T Alexander Wheeler"
Unlabelled: In the age of long read sequencing, genomics researchers now have access to accurate repetitive DNA sequence (including satellites) that, due to the limitations of short read-sequencing, could previously be observed only as unmappable fragments. Tools that annotate repetitive sequence are now more important than ever, so that we can better understand newly uncovered repetitive sequences, and also so that we can mitigate errors in bioinformatic software caused by those repetitive sequences. To that end, we introduce the 1.
View Article and Find Full Text PDFIntroduction And Hypothesis: This manuscript is a part of the International Urogynecology Consultation (IUC) on pelvic organ prolapse (POP) chapter three, committee three, on the impact of lifestyle modifications (i.e., weight loss, treatment of constipation, activity restriction, etc.
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- - Molecular Dynamics (MD) simulations help us understand how biomolecules change shape and interact, which is crucial for insights into their behavior and drug interactions.
- - There's a need for an open access repository for storing and sharing these simulations, as currently, they are scattered and lack a consistent organization.
- - MDRepo is introduced as a solution, offering a standardized way to contribute, analyze, and visualize MD simulations, built on the CyVerse infrastructure to handle large amounts of data efficiently.
Immunotherapy has changed the treatment paradigm for many types of cancer, but immune checkpoint inhibitors (ICIs) have not shown benefit in prostate cancer (PCa). Chronic inflammation contributes to the immunosuppressive prostate tumor microenvironment (TME) and is associated with poor response to ICIs. The primary source of inflammatory cytokine production is the inflammasome.
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