Publications by authors named "T Akutsu"
In semelparous species like the ayu (), spawning is followed by rapid physiological decline and death; yet, the underlying molecular mechanisms remain largely unexplored. This study examines transcriptomic changes in ayu skeletal muscle before and after spawning, with a focus on key genes and pathways contributing to muscle atrophy and metabolic dysfunction. Through RNA sequencing and DEG analysis, we identified over 3000 DEGs, and GSEA and KEGG pathway analysis revealed significant downregulation of energy metabolism and protein degradation.
View Article and Find Full Text PDFBackground: Pulmonary nocardiosis is a rare opportunistic infection, with approximately 15 % of patients being immunocompetent. The isolation rate of Nocardia spp. has recently increased, indicating rising clinical concern.
View Article and Find Full Text PDFArticle Synopsis
- This letter focuses on analyzing the depth and width of autoencoders that utilize rectified linear unit (ReLU) activation functions, comparing them to previous studies using linear threshold activation functions.
- Autoencoders consist of an encoder that compresses input data and a decoder that reconstructs it, and the research shows that similar theoretical findings apply to both types of activation functions when dealing with real input/output vectors.
- The study also reveals that while it is feasible to compress input vectors to one-dimensional vectors with ReLU, the efficiency of linear activation functions is significantly lower than that of ReLU-based autoencoders.
The high specificity of the human skin microbiome is expected to provide a new marker for personal identification. Metagenomic sequencing of clustered regularly interspaced short palindromic repeats (CRISPRs), which we call metaCRISPR typing, was shown to achieve personal identification accurately. However, the intra-individual variability observed in previous studies, which may be due to poor DNA yields from skin samples, has resulted in non-reproducible results.
View Article and Find Full Text PDFArticle Synopsis
- Extracorporeal membrane oxygenation (ECMO) offers temporary support for patients with severe trauma, and this study examines the outcomes of patients treated with veno-arterial ECMO (V-A ECMO) in Japan between 2019 and 2021.
- Out of 72,439 severe trauma patients, only 51 received V-A ECMO, with a discharge survival rate of 31.3%.
- The findings suggest that V-A ECMO may be beneficial in severe trauma cases, particularly where traditional interventions aren't effective, but further research is needed to clarify its indications.