Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes.

Prion diseases represent a novel form of infectivity caused by the propagated misfolding of a self-protein (PrP(C)) into a pathological, infectious conformation (PrP(Sc)). Efforts to develop a prion vaccine have been complicated by challenges and potential dangers associated with induction of strong immune responses to a self protein. There is considerable value in the development of vaccines that are specifically targeted to the misfolded conformation.

Student evaluations of the portfolio process.

Objective: To evaluate pharmacy students' perceived benefits of the portfolio process and to gather suggestions for improving the process.

Methods: A questionnaire was designed and administered to 250 first-, second-, and third-year pharmacy students at the University of Arizona College of Pharmacy.

Results: Although the objectives of the portfolio process were for students to understand the expected outcomes, understand the impact of extracurricular activities on attaining competencies, identify what should be learned, identify their strengths and weaknesses, and modify their approach to learning, overall students perceived the portfolio process as having less than moderate benefit.

The impact of road construction on the spatial characteristics of hospital utilization in the Meru district of Kenya.

This paper examines the effect of road construction on the catchment area of a church hospital. It is hypothesized that the new road will reduce the spatial and travel cost relationships for the hospital's patients. Analysis of the data suggests that the space-reducing effect of the new road is more important than its effect on travel costs.

The impact of road construction on hospital in-patient catchments in the Meru District of Kenya.

This paper examines the effects of road improvements on in-patient catchments for two mission hospitals in Kenya. Two hypotheses, that the road improvements will widen and intensify the use of the two hospitals by more distant populations are tested. They are only partially upheld; the main impact of the new road has been in the shortening of the road distance to the hospitals rather than improving geographical accessibility.