Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study.

Background: Accidental hypothermia, recognized by core temperature below 35 °C, is a lethal condition with a mortality rate up to 25%. Hypothermia-induced cardiac dysfunction causing increased total peripheral resistance and reduced cardiac output contributes to the high mortality rate in this patient group. Recent studies, in vivo and in vitro, have suggested levosimendan, milrinone and isoprenaline as inotropic treatment strategies in this patient group.

Identifying the barriers to kidney transplantation for patients in rural and remote areas: a scoping review.

Background: Populations in rural and remote areas have higher rates of chronic kidney disease and kidney failure than those in urban or metropolitan areas, and mortality rates for chronic kidney disease are almost twice as high in remote areas compared to major cities. Despite this, patients residing in regional, rural, or remote areas are less likely to be wait-listed for or receive a kidney transplant. The objective of this scoping review is to identify specific barriers to kidney transplantation for adult patients residing in rural and remote areas from the perspectives of health professionals and patients/carers.

Does Enhanced Structural Maturity of hiPSC-Cardiomyocytes Better for the Detection of Drug-Induced Cardiotoxicity?

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are currently used following the Comprehensive in vitro Proarrhythmic Assay (CiPA) initiative and subsequent recommendations in the International Council for Harmonization (ICH) guidelines S7B and E14 Q&A, to detect drug-induced cardiotoxicity. Monocultures of hiPSC-CMs are immature compared to adult ventricular cardiomyocytes and might lack the native heterogeneous nature. We investigated whether hiPSC-CMs, treated to enhance structural maturity, are superior in detecting drug-induced changes in electrophysiology and contraction.

Mercury's Crustal Thickness and Contractional Strain.

The crust of Mercury has experienced contraction on a global scale. Contractional deformation is expressed by a broadly distributed network of lobate thrust fault scarps. The most likely principal source of stress is global contraction from cooling of Mercury's interior.

A case for limited global contraction of Mercury.

Mercury is a one-plate planet that has experienced significant radial contraction primarily driven by interior cooling. In some previous studies aimed at estimating the total magnitude of contraction, numerous faults are assigned to positive relief landforms, many without evidence of origin by deformation, resulting in estimates of planetary radius reduction as large as 7 km. Here we use high-incidence angle image mosaics and topography from the MESSENGER mission to map Mercury's contractional landforms.