[The proteomic profiling of blood serum of children with gastroesophageal reflux disease].

The mass-spectra of proteome of blood serum from healthy children and children with gastroesophageal reflux disease were received. The technology platform including direct proteome mass-spectrometer profiling after pre-fractional rectification using magnetic particles MB WCX was applied. The significant differences in mass-spectra were established manifesting in detection of more mass-spectrometer peaks and higher indicators of their intensity and area in group of healthy children.

[Features of mucosal lesions of stomach and duodenum in children with chronic gastroduodenitis with different microflora content].

Objective: Our aim was to reveale the features of histological mucosa with different composition of the microflora of stomach and duodenum in children with chronic gastroduodenitis.

Methods: The study included 122 children with chronic gastroduodenitis from 5 to 17 years old. All patients underwent endoscopy with histology of biopsy specimens of gastric and duodenal mucosa in 94 patients and in 48 patients among them with morphometry of biological material.

[Changes of epidermal growth factor level in blood serum, saliva and gastric juice in children with duodenal ulcer].

Aim: The aim of our study is to investigate EGF content in biological mediums in children with duodenum ulcer depending on phase of the disease and different variants of its course.

Materials And Methods: The present study was performed in Federal State Establishment "Nizhniy Novgorod Research Institute of Children Gastroenterology", Nizhniy Novgorod, Russia. 92 children, between the ages of 8 to 17, with duodenum ulcer were under observation.

[Liver detoxifying function disorders in children with chronic hepatic disease and their correction].

In the present study liver detoxifying function state in children with chronic hepatitis and pigmentary hepatosis was examined. An endogenous intoxication level increase, peroxide processes and biotransformation system activation were established against the background of endotoxicosis substrate accumulation in blood. The dynamics of clinical symptoms and liver detoxifying function indicators was estimated against the background of the complex treatment with Reamberin.

[Content of epidermal growth factor in biosubstrates and macrophage count in defect healing in children and adolescents with duodenal ulcer disease].

The concentrations of epidermal growth factor (EGF) in saliva, gastric juice, and blood and those of macrophages in mucosal biopsy specimens were determined in children with duodenal ulcer disease. The maximum level of EGF was noted in the saliva. There were unidirectional positive changes in the levels of EGF and macrophages during ulcerative defect healing.