[The cytokine profile in the acute period of tick-borne neuroinfections in children].

Clinical peculiarities and blood levels of several cytokines were studied in 199 children, aged from 1 to 15 years, in the acute period of different tick-borne infections. The mixed infection manifested itself by the more severe progression of general clinical presentations compared to monoinfections. Etiologically unspecific changes of blood concentrations of cytokines in the acute period of the disease were found.

[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].

We studied the peculiarities of functional activity of peripheral blood leukocytes in different etiological variants and clinical forms of tick-borne infections in 629 children aged from 1 to 14 years. The decrease of biocide potential of neutrophils was accompanied by most severe clinical manifestations. The analysis of changes in defensin levels in different clinical forms of tick-borne infections revealed the most significant changes in cases of mixed infection.

[Role of sex hormones in the development of atherogenic dyslipoproteinemia in boys of pubertal age].

Interrelationships of hypercholesterolemia (HCS), hypertriglyceridemia (HTG) or hypo-alpha-cholesterolemia (hypo-CS HDL) and the blood levels of sex hormones were investigated in boys aged 14-15 to detect variations in the levels of sex hormones to define groups of adolescents at the highest risk of developing atherogenic dyslipoproteinemia (DLP). A conclusion has been made that HCS and hypo-CS HDL development is associated with changes in the blood levels of testosterone and estradiol, and a low blood level of T in HTG is of secondary origin with regard to the development of this type of DLP.