Publications by authors named "T A Travis"
Burn injury results in hypercoagulability and an increased venous thromboembolism risk. However, the most effective chemoprophylaxis for burn-injured patients has yet to be elucidated. Therefore, this study aims to identify the safety and efficacy of a burn center's venous thromboembolism protocol modification which increased the dose of enoxaparin from 40mg daily to 40mg twice daily with peak anti-Xa level adjustments.
View Article and Find Full Text PDFIntroduction: Plasma inclusive resuscitation (PIR) uses fresh frozen plasma as an adjunct to crystalloid in the management of burn shock and has potential benefits over other colloids. Yet, safety concerns for transfusion-related acute lung injury (TRALI) exist. The aim of this study evaluated the association between TRALI and PIR in a cohort of severely burn-injured patients using the updated Canadian Blood Services Consensus definitions.
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- Dynamically titrated crystalloids are the primary method for treating burn shock, and this study investigates whether adding allogeneic plasma (known as plasma-inclusive resuscitation, or PIR) affects coagulation negatively.
- The study involved 35 patients treated with PIR, analyzing their blood to check for coagulopathy at multiple points during treatment, finding no significant coagulation issues or complications like transfusion reactions.
- Results indicate that PIR does not cause harmful blood clotting changes compared to baseline in burn patients, suggesting it may be safe, but further research is necessary to confirm these results and assess its effectiveness in burn resuscitation.
Article Synopsis
- The study investigates the effectiveness of combining autologous skin cell suspension (ASCS) with meshed split-thickness skin grafts (mSTSG) for treating large burns, aiming to improve healing times and reduce aesthetic issues.
- Experiments conducted on pigs showed that wounds treated with ASCS had significantly faster re-epithelialization rates compared to those without ASCS, particularly noted on days 3, 5, and 7 post-grafting.
- However, despite the improved healing rates, the presence of ASCS did not affect the patterning of the scars, indicating that while ASCS enhances healing, it may not address visual scarring issues.
Comprehensive studies on the incidence, risk factors, and prophylactic measures related to venous thromboembolism (VTE) are lacking in burn care. This study characterizes VTE risk and existing prevention measures to improve and inform overall patient care in the field of burn care on a national scale. The US National Trauma Data Bank (NTDB) was queried from 2007 to 2021 to identify burn-injured patients.
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