Publications by authors named "T A Tomberg"
This study reports the application of stimulated Raman scattering (SRS) microscopy for real-time chemically specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASDs). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS microscopy with fast spectral focusing to analyze ASD behavior upon contact with a dissolution medium. Multivariate unmixing of the SRS spectra allowed changes in the distributions of the drug, polymer, and water to be (semi)quantitatively imaged in real time, both in the film and the adjacent dissolution medium.
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- This study focuses on the process of creating co-crystals of active pharmaceutical ingredients (APIs) and highlights the importance of understanding co-crystallization behaviors under different conditions.
- The researchers utilized two advanced imaging techniques, narrowband CARS and hyperspectral SRS, to observe co-crystallization in real-time, revealing key differences in component identification and overall co-crystal formation.
- The findings provide new insights into the co-crystallization process, including unexpected trace forms and the influence of ethanol content on co-crystal stability during milling.
During recent years there have been shortages of certain drugs due to problems in raw material supply. These are often related to active ingredients but could also affect excipients. Lactose is one of the most used excipients in tableting and comes in two anomeric and several solid-state forms.
View Article and Find Full Text PDFThe importance of ink rheology to the outcome of 3D printing is well recognized. However, rheological properties of printing inks containing drug nanocrystals have not been widely investigated. Therefore, the objective of this study was to establish a correlation between the composition of nanocrystal printing ink, the ink rheology, and the entire printing process.
View Article and Find Full Text PDFIn this Letter, we report on the sub-parts-per-billion-level radiocarbon dioxide detection using cantilever-enhanced photoacoustic spectroscopy. The / ratio of samples is measured by targeting a absorption line with minimal interference from other isotopes. Using a quantum cascade laser as a light source allows for a compact experimental setup.
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