Posterior stabilization in total knee arthroplasty with use of an ultracongruent polyethylene insert.

Fifty-three primary and 47 revision posterior cruciate ligament (PCL)-substituting total knee arthroplasties (TKAs) using a highly conforming (ultracongruent) polyethylene insert were retrospectively reviewed over a 48- to 106-month (mean, 60+/-11 months) follow-up period. These 100 knees were age and sex matched with another 100 TKAs performed using a PCL-sparing design. The ultracongruent design has an anterior buildup of 12.

Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites.

The human C epsilon gene produces a number of alternatively spliced heavy chain transcripts of which some encode functional IgE isoforms. We now show that differentially processed epsilon mRNA variants also exist in the mouse and are generated by differential polyadenylation and alternative splicing of primary epsilon chain transcripts. The two poly(A) sites of the mouse membrane transcripts were identified in the present study by RACE-PCR analysis.

Patellar component medialization in total knee arthroplasty.

Intraoperative correction of patellar maltracking has traditionally involved the use of a lateral retinacular release. Problems, however, related to lateral retinacular release include increased postoperative pain and wound healing complications, compromised patellar blood flow, and longer rehabilitation. The purpose of this study was to assess the effect of patellar medialization in total knee arthroplasty.

6- to 10-year experience using countersunk metal-backed patellas.

Three hundred two consecutive cementless total knee arthroplasties (Natural Knee, Intermedics Orthopedics, Inc., Austin, TX) were performed using a metal-backed, porous-coated patellar component. Fifty-nine patients died and 31 were lost to follow-up evaluation, resulting in 212 knees available for evaluation at 6 to 10 years.

Expression of CD44 splice variants in metastatic and non-metastatic mouse tumour cell lines.

Different splice variants of the CD44 cell-surface molecule have been linked to metastasis formation in several animal and human cancers. We have used metastatic CSML-100 and non-metastatic CSML-0 mouse adenocarcinoma cell lines to determine whether variant CD44 molecules could be implicated in the different behaviour of these cells. Two CD44 splice variants containing exons v7-v10 and v8-v10 were detected in the non-metastatic CSML-0.