Publications by authors named "T A Sidorova"
Article Synopsis
- The study examines how juvenile Baikal whitefish, both preadapted and non-adapted, respond at the genetic level to heat shock after being exposed to temperature changes during their development.
- Preadapted fish experienced a controlled thermal rise during their growth, while both groups were tested under standard and increased temperature conditions to measure gene expression responses.
- The findings show that preadapted fish had heightened expression in genes related to immune response and growth, while non-adapted fish showed increased activity in metabolism-related genes, highlighting differences in how these two groups handle thermal stress.
Acclimation during Embryogenesis Remodulates Telomerase Activity and Gene Expression in Baikal Whitefish Larvae, Mitigating the Effects of Acute Temperature Stress.
Animals (Basel)
October 2024
Article Synopsis
- Acclimation through the hormesis effect enhances flexibility in organisms, which has been confirmed in various ectothermic species, including the Baikal whitefish, by examining telomere length and gene expression.
- The study found that while acclimation and acute temperature stress did not affect telomere length, they did influence telomerase activity, with acclimated larvae showing decreased activity and stressed larvae showing increased activity.
- Acclimated larvae exhibited increased expression of genes involved in antioxidant defense, indicating a better ability to manage oxidative stress compared to non-acclimated larvae, along with changes in telomere-related gene expression under stress.
The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype-genotype relationships and tissue response to pharmacological manipulation. Mutations in the and genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys.
View Article and Find Full Text PDFThis paper investigates the antagonistic and plant growth promotion activity of the new indigenous bacteria antagonist strains BZR 245-F and sp. BZR 523-2. It was found that on the 10th day of cultivation, BZR 245-F and BZR 523-2 exhibit an antagonistic activity against at the level of 59.
View Article and Find Full Text PDFAim: To investigate the specific mechanisms of action of Fertiwell in a mouse model of D-galactose-induced aging of the reproductive system.
Materials And Methods: C57BL/6J mice were randomized into four groups: intact mice (control group), a group of mice with artificial accelerated aging treated with D-galactose alone (Gal), D-galactose followed by Fertiwell (PP), and D-galactose followed by a combination of L-carnitine and acetyl-L-carnitine (LC). The artificial accelerated aging of reproductive system was induced by daily intraperitoneal administration of D-galactose at a dose of 100 mg/kg for 8 weeks.