[NADPH-diaphorase topochemistry in human and rat knee joint structures and its changes in experimental arthritis].

Using the histochemical demonstration of NADPH-diaphorase (NADPH-d) activity, the distribution of constitutive nitric oxide synthase (NOS) activity was studied in the cartilage and synovium of healthy man and rats and in experimental arthritis. Arthritis was induced in rats by the injection of complete Freund's adjuvant; the material was studied at days 7, 14, 30 and 60 of inflammation. NADPH-d activity was different in man and rat.

[Effect of epidural morphine analgesia on the NO-forming activity of nociceptive neurons of the spinal ganglia and bone marrow].

The effect of epidural morphine analgesia on NO mechanisms was studied during the primary and secondary sensitizations. The nitro-oxide synthase (NOS) activity was evaluated by the method of Home and Vincent, 1989, (identification of NADPH diaphorase). NOS and NADPH diaphorases are two double enzymes in cells with a synchronously changing activity.

[Effect of epidural morphine anesthesia on NO-ergic activity of nociceptive neurons of spinal ganglia and spinal cord].

The effect of epidural morphine anesthesia on NO-ergic mechanisms was studied during primary and secondary sensitization. Nitro-oxide synthase (NOS) activity was evaluated by the method of Home and Vincent (1989) (identification of NADPH diaphorase). NOS and NADPH diaphorase are two double enzymes in cells with synchronously changing activity.

[Nitric oxidergic neurons of the respiratory organs].

Using histochemical NADPH-diaphorase reaction NO-ergic neurons distribution in human tracheobronchial tree was studied in man and mammals. Psedounipolar sensory neurons forming microganglia mark in adventitia of the trachea posterior surface from superior border up to trachea bifurcation. It was suggested that protoneurons are the constant structural formations of respirator organs.