[The detection of circadian fluctuations in the efficacy of pharmacotherapy in patients with ischemic heart disease using cardiointervalography].

Circadian variations of various parameters of the cardiointervalogram were observed in patients with ischemic cardiac disease. Analysis of the regularities found makes it possible to determine and predict the therapeutic efficacy of beta-adrenoblocking drugs and calcium antagonists.

[A mathematical analysis of the cardiac activity indices in patients with ischemic heart disease undergoing antianginal pharmacotherapy].

Taking into account various parameters of heart rhythm variability makes it possible to differentiate patients with ischemic heart disease by their response to antianginal pharmacotherapy. The cardiointervalographic method may be used to predict therapeutical effects in making clinical and pharmacological decisions.

[The chronobiological aspects of drug resistance to antianginal therapy].

Two groups of ischemic heart disease patients with different responses to antianginal therapy (propranolol, nifedipine) were studied. Mathematical analysis of heart rate variabilities showed that tolerant patients had a low index of centralization, lack of its circadian rhythm and a low correlation between several cardiointervalographic parameters. Bearing in mind these shifts makes it possible to predict the therapeutical efficiency of the antianginal drugs.

[Characteristics of circadian variations in the cardiointervalogram of patients with ischemic heart disease].

The analysis of heart rate in patients with ischemic heart disease revealed its differences in different periods of a day. In severe disease forms, the daily fluctuation range of some cardiointervalogram parameters is higher and their acrophase is shifted to the night and early morning hours.