Publications by authors named "T A Saari"
Aim: The aim of the study was to survey the observed incidence of adverse effects (AEs) related to electroconvulsive therapy (ECT) in Finnish neuromodulation units, as well as to explore what medical interventions are used to prevent and treat them in those units.
Methods: An electronic survey was conducted among Finnish neuromodulation units at the end of 2022. The survey included 35 questions related to AEs and their prevention and/or treatment in the responding units' ECT patient populations.
Article Synopsis
- The study explored the link between food insecurity (FI) and diet quality among service workers in Finland, using data collected from questionnaires and national statistics.
- Results showed that those with severe FI had significantly lower diet quality scores compared to food-secure individuals, with poor intake of essential food groups like fruits, vegetables, and whole grains.
- The findings suggest that individuals facing severe FI have a higher risk of poor dietary habits, potentially leading to chronic health issues.
Background: New biomarkers that improve diagnosis of Alzheimer's disease (AD) are warranted. Tear fluid (TF) containing variety of proteins that reflect pathophysiological changes of systemic diseases makes TF proteins potential biomarker candidates for AD.
Objective: We investigated the expression levels of TF proteins in persons with mild AD and cognitively healthy controls (CO) to find out if altered proteins may link to the AD pathophysiology.
Article Synopsis
- - The study evaluates the Center for Epidemiological Studies-Depression scale (CES-D) to determine its effectiveness in measuring depression among older adults, specifically those aged 90+ and with cognitive impairments.
- - Using data from two Finnish twin studies, the research found consistent factor structures across various CES-D versions and confirmed their applicability for different age and cognitive statuses.
- - Findings indicate that higher genetic risk for major depressive disorder correlates with increased depressive symptoms, suggesting that the CES-D can effectively assess depression in older populations.
Article Synopsis
- Researchers studied how different genetic variations in the CYP2D6 enzyme affect the body's ability to metabolize codeine into morphine, which is vital for determining pain relief and potential side effects.
- A clinical trial involving 1000 patients was conducted, where their CYP2D6 genotypes were analyzed after they were given a standard dose of codeine, and the relationship between their genetic makeup and morphine exposure was modeled.
- The results showed that individuals with certain genetic variations (like CYP2D6*10 and *41) had less effective metabolism of codeine, leading to significantly higher or lower morphine levels in the bloodstream, highlighting the importance of genetic testing for safer opioid prescribing.