Relationship between muscle power, muscle volume and limb length in healthy male and female adolescents.

Objective: Muscle power is essential for the activities of daily living. Muscle power production depends on numerous factors such as muscle size and length, muscle architecture and fiber type and varies with age during growth. The association between muscle power output during a jump and lower limb muscle volume and length in adolescents is largely unknown.

An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation.

Gene editing technologies hold promise for enabling the next generation of adoptive cellular therapies. In conventional gene editing platforms that rely on nuclease activity, such as clustered regularly interspaced short palindromic repeats CRISPR-associated protein 9 (CRISPR-Cas9), allow efficient introduction of genetic modifications; however, these modifications occur via the generation of DNA double-strand breaks (DSBs) and can lead to unwanted genomic alterations and genotoxicity. Here, we apply a novel modular RNA aptamer-mediated Pin-point base editing platform to simultaneously introduce multiple gene knockouts and site-specific integration of a transgene in human primary T cells.

Influence of muscle volume on jumping performance in healthy male and female youth and young adults.

Background: Sex differences that appear throughout puberty have a substantial impact on the training process. It remains unclear what effect these sex differences should have on how training programs are planned and performed and what objectives should be established for boys and girls of different ages. This study aimed to investigate the relationship between vertical jump performance and muscle volume based on age and sex.

Fuel cell-based electric vehicles technologies and challenges.

Electric vehicles (EVs) are becoming popular and are gaining more focus and awareness due to several factors, namely the decreasing prices and higher environmental awareness. EVs are classified into several categories in terms of energy production and storage. The standard EV technologies that have been developed and tested and are commercially available include the fuel cell electric vehicles (FCEVs), the battery-electric vehicles, the plug-in hybrid electric vehicles, the hybrid electric vehicles, and the flexible fuel vehicles.

miRNome and Proteome Profiling of Small Extracellular Vesicles Secreted by Human Glioblastoma Cell Lines and Primary Cancer Stem Cells.

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite available therapeutic interventions, it is very difficult to treat, and a cure is not yet available. The intra-tumoral GBM heterogeneity is a crucial factor contributing to poor clinical outcomes.