[Herpesvirus infection in patients with chronic glomerulonephritis].

Virological examinations of blood, urine and saliva in 75 patients with chronic glomerulonephritis (CG) revealed, in 95% of them, herpes-virus infections caused by herpes simplex virus, type 1 (34.4%), herpes simplex virus, type 2 (2.6%) and cytomegalovirus (12%) or mixed infections (46%).

[The laboratory diagnosis of cytomegalovirus infection in infants in the first months of life].

The detection rate of IgM, specific to cytomegalovirus (CMV), in the umbilical blood was 2.0 +/- 1.8% in infants with antenatal complications in their medical history, 8.

[Viral antigens in kidney biopsies of children with glomerulonephritis].

A relationship between clinical forms of glomerulonephritis and incidence of viral antigens in renal tissue was revealed: Hepatitis B virus antigens (HBsAg) are more frequently detected in the glomeruli in the patients with nephrotic glomerulonephritis, Herpes simplex antigens are detected in the glomeruli in mixed glomerulonephritis, and cytomegaloviral and Herpes simplex antigens are detected in the epithelium of the proximal canaliculi in patients with hematuric glomerulonephritis. No correlations between the persistence of Herpes simplex type 1, cytomegalovirus, and HBsAg in the renal tissue were detected. HBsAg is detected in the renal tissue mainly in the children without free HBsAg in the blood serum.

[Selection of primers and their use in the polymerase chain reaction for diagnosing infections caused by herpes simplex virus and cytomegalovirus].

The authors present the results of studies on the construction of highly sensitive primers for rapid diagnosis of infections caused by Herpes simplex virus (HSV) and cytomegalovirus. An oligonucleotide primer to HSV-1 is described, which permits detection of HSV-1 DNA in infected cultures and in clinical material in dilution 10(-7), whereas the "universal" primer constructed on the basis of published data detects both HSV-1 and HSV-2 only in dilution 10(-4). Study of the clinical material in polymerase chain reaction (PCR) vs.

[The antitumor action of double-stranded interferon inducers (larifan, ridostin) and reaferon in an experiment].

Interferon inducers larifan and rhidostin, and reaferon were shown to exert an inhibiting antitumor effect manifested in the prolongation of the incubation period, decrease of the size of tumors, and longer survival of the animals. The maximal anti-tumor and immunomodulating effect was obtained by combined use of preimmunization with tumor cells and simultaneous administration of reaferon or interferon inducers, larifan and rhidostin. Larifan was also shown to have a greater antitumor activity than rhidostin.