Implementation of a high complexity nursing service in pediatric oncology.

Objective: to analyze how the process of implementing an onco-hematology nursing service at a pediatric hospital in Rio de Janeiro took place.

Methods: a historical, qualitative study. Sources included written and oral documents, produced through semi-structured interviews, carried out between August 2022 and February 2023 with nurses who worked on implementing the service, represented by 40 minutes, nine care protocols and eight reports from the hospital's internal website.

Environmental enrichment reverses cognitive impairments and hippocampus tissue loss without altering the redox state in rats exposed to severe chronic hyperhomocysteinemia.

Introduction: Classical homocystinuria is a genetic disease caused by partial or total deficiency of cystathionine-β synthase (CβS) enzyme activity, ultimately leading to brain alterations and early atherosclerotic disease. Currently, there is no cure for the disease and the treatments consist in reducing homocysteine levels through diet, however not all patients respond to therapy. Due to its ability to increase neurotrophins production and decrease oxidative stress in the brain, environmental enrichment (EE) has been used with success as an adjuvant non-pharmacological therapy for CNS disorders.

A new approach to dilution prediction of underground mine gold using computing techniques.

Controlling ore dilution in underground mining is challenging. In this study, data from a Brazilian gold mine were analyzed, covering 70 chambers and 26 variables. Six key variables were identified through decision tree analysis, forming the basis of a predictive model using advanced soft computing techniques.

Temporal trend of breast cancer burden among younger and older Brazilian women, 1990-2019.

Objective: To analyze the temporal trend of the burden of breast cancer in Brazilian women under 40 years of age compared to the age group over 40 years of age, between 1996 and 2019.

Methods: An ecological time trend study was conducted in Brazil between 1996 and 2019 using data from the Global Burden of Disease (GBD) study. The segmented regression method (Joinpoint Regression) was applied to analyze rates among women under and over 40 years of age.

Fertility programs for lactating dairy cows: a novel Presynch + Timed AI program (Double E-Synch) produces similar ovarian dynamics, synchronization, and fertility as Double-Ovsynch.

Fertility programs were implemented for the first postpartum timed-AI (TAI) in 800 (primiparous and multiparous) lactating dairy cows, evaluating 2 presynchronization (presynch) strategies and 2 TAI protocols, in a 2 × 2 factorial arrangement. Weekly, cows were enrolled into 1 of 4 groups (Ovs+Ovs [Double-Ovsynch], Ovs+OvsP4/E2, PreP4/E2+Ovs and PreP4/E2+OvsP4/E2 [Double E-Synch). On d -17 (34 ± 3 d in milk), the Ovs presynch was initiated with 10 µg of buserelin acetate (GnRH), and cows received 0.