[Selective accumulation of 131I-labeled IKO-1 monoclonal antibodies in the tissues of mouse L 1210 lymphoid leukemia].

Monoclonal antibodies (MCA) ICO-1 of IgG3 isotype against 1a-like human antigens were labelled with 131I using chloramine T; a radionuclide-bound fraction was isolated by radiochromatography. Basing on the results of assessment of complement-dependent cytotoxicity against lymphocytes from the lymph nodes of BDF1 mice a conclusion was made that MCA immunological reactivity changed slightly after radionuclide tracer administration. In vitro experiments with a panel of normal and malignant cells showed 131I-MCA binding with cells of mouse lymphoid leukemia L1210 and hemocytoblastosis La as well as with spleen and lymph node normal lymphocytes.

[Dosimetric characteristics of internal irradiation with radioactive nuclides of iodine].

The paper is concerned with some data on mean absorbed dose values in the animals' organs, the time course of their formation and the character of microdistribution of an absorbed dose around thyroid follicles in internal irradiation of the rat body with 131I and 125I. A raised level of irradiation of the animals' pituitary body is noted. The authors provide dosimetric characteristics of irradiation of thyroid microstructures noting that 125I creates more inhomogeneous distribution of an absorbed dose around thyroid follicles compared to 131I, irradiating, to a greater extent, the follicular membrane and, to a lesser degree, the nuclei of surrounding cells whereas 131I provides homogeneous irradiation of thyroid cells.

[Comparative biological effectiveness of 125I and 131I].

An experimental study of comparative biological efficacy of 125I and 131I at equal absorbed doses (2.3 and 13 Gy) in the thyroid of rats showed that the blastomogenic effect of both radionuclides was almost the same. Sex differences were found in the development of long-term consequences (20 mos.