Publications by authors named "T A Nirmal Peiris"

is a well-studied genus in the family Callistosporiaceae (Basidiomycota). Currently, the genus comprises eight species with worldwide distribution. All species in this genus are relatively large compared to other edible mushrooms and are commonly consumed by locals.

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Purpose: To evaluate the tolerability of utilizing Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) as a drug delivery device for preservative-free cyclosporine 0.05% for the treatment of dry eye disease.

Patients And Methods: Fourteen current daily PROSE wearers were enrolled, with four screen failures and one subject that did not complete the study protocol due to burning and stinging.

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Purpose: To evaluate the prevalence and risk factors for development of paravascular inner retinal defects (PIRDs) using en face optical coherence tomography.

Methods: This is a retrospective cross-sectional study. En face and cross-sectional optical coherence tomography images were reviewed (9 × 9 mm or 12 × 12 mm).

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Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired immunity. These constraints make it difficult to define the relevance of necroptosis in diseases such as chronic and persistent viral infections and within individual organ systems. The role of necroptotic signalling is further complicated because proteins essential to this pathway, such as receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL), have been implicated in roles outside of necroptotic signalling.

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Article Synopsis
  • NPHS2 variants are the leading cause of steroid-resistant nephrotic syndrome in children, with specific missense variants affecting protein trafficking of PODOCIN in podocytes, based on studies using nonpodocyte cell lines.
  • Researchers created human iPSC lines with pathogenic NPHS2 variants and differentiated them into kidney organoids to observe the effects on PODOCIN expression and subcellular localization.
  • The study found that NPHS2 variants altered PODOCIN localization in podocytes, with some variants causing accumulation in the endoplasmic reticulum or Golgi, leading to insights into how these mutations disrupt podocyte function and contribute to the disease.
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