Publications by authors named "T A Moura"
Objective: The objective of this review will be to synthesize the best available evidence on fathers' lived experiences of fatherhood during the child's first 1,000 days of life.
Introduction: Involved and caring fatherhood is crucial for the healthy cognitive, physical, social, and emotional development of children. However, fatherhood is a challenging process for most men.
Background: Type 1 diabetes (T1D) results in autoreactive T cells chronically destroying pancreatic islets. This often results in irreplaceable loss of insulin-producing beta cells. To reverse course, a combinatorial strategy of employing glucose-responsive insulin restoration coupled with inhibiting autoreactive immune responses is required.
View Article and Find Full Text PDFBackground: Cutaneous Leishmaniasis (CL) is a neglected tropical disease endemic in Brazil. Morbidity and disabilities caused by CL lesions require an analysis of a Global Burden of Disease (GBD), which would help discern the impact on the Brazilian population. Herein, we assess the burden of CL and its spatial and temporal patterns in Brazil between 2001 and 2021.
View Article and Find Full Text PDFAdvancements in genome-wide sequence analysis have led to the discovery of numerous novel bacterial non-coding RNAs (ncRNAs). These ncRNAs have been categorized into various RNA families and classes based on their size, structure, function, and evolutionary relationships. One such ncRNA family, raiA, is notably abundant in the bacterial phyla Firmicutes and Actinobacteria and is remarkably well-conserved across many Gram-positive bacteria.
View Article and Find Full Text PDFArticle Synopsis
- ISG15 deficiency is a rare inherited syndrome that leads to frequent infections by less harmful mycobacteria and interferon-related issues, and this study focuses on two unrelated Brazilian patients sharing the same genetic mutation in the ISG15 gene.
- Assessments revealed both patients had low production of IFN-γ and distinct clinical symptoms, impacting their immune response and leading to both infectious and neurological manifestations.
- The researchers identified a specific mutation (c.83 T > A) that destabilizes the ISG15 protein, along with a significant number of differentially expressed genes linked to immune pathways, marking the first documentation of these cases in Brazil.