Publications by authors named "T A Moss"
Arylative dearomatization forms quaternary stereocenters in cyclic systems with the concomitant introduction of an aromatic ring. Pd-catalyzed arylative dearomatization, which uses conditions analogous to cross-coupling, has emerged as a powerful method in an intramolecular context. But translating this from intramolecular cyclizations to an intermolecular process has proven extremely challenging: examples are scarce, and those that exist have not been rendered enantioselective, despite the potential for broad application in medicinal chemistry and natural product synthesis.
View Article and Find Full Text PDFMaternal asthma is associated with increased rates of neonatal lung disease, and fetuses from asthmatic ewes have fewer surfactant-producing cells and lower surfactant-protein B gene (SFTPB) expression than controls. Antenatal betamethasone increases lung surfactant production in preterm babies, and we therefore tested this therapy in experimental maternal asthma. Ewes were sensitised to house dust mite allergen, and an asthmatic phenotype induced by fortnightly allergen lung challenges; controls received saline.
View Article and Find Full Text PDFArticle Synopsis
- - Collective cell migration is important for processes like development, healing, and cancer spread, and in the study of Drosophila, border cells (BCs) migrate with the help of a kinase called Misshapen (Msn).
- - The protein Tao serves as an important activator of Msn in border cells; reducing Tao levels hinders BC migration, mimicking the effects of a loss of Msn function.
- - Msn's distribution is influenced by its interaction with a protein called Rap2l, which assists in transporting Msn to the endolysosomal pathway for degradation; this process is critical for maintaining balanced Msn levels and activity in BCs.
Article Synopsis
- A study looked at how often dogs have problems after getting blood transfusions, focusing on 858 dogs that received 1,542 transfusions from March to November 2022.
- Out of the dogs, 8.9% experienced acute reactions when they got packed red blood cells, and 4.5% had reactions after receiving plasma products.
- The study found that older stored blood and higher doses were linked to more reactions, so vets should pay attention to these factors when treating dogs.