Publications by authors named "T A Mishina"
POEMS syndrome is a multisystemic disease associated with monoclonal plasma cell disorders. Although the presence of bone lesions is included in the diagnostic criteria, their precise manifestations remain unknown. Here, we retrospectively analyzed the bone lesions in patients with POEMS syndrome and evaluated their clinical features.
View Article and Find Full Text PDFThe frequency of bronchial branching abnormalities is about 0.6%, of which about 75% are related to the right upper lobe. The frequency of left B transition bronchus is even rarer, but a few cases have been reported.
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- Floodplains are rich ecosystems affected by climate change and human actions, leading to many endangered species, like the Itasenpara bitterling fish in Japan, which needed population history studies for conservation efforts.
- Researchers used genetic sequences to analyze the bitterling's population structure and found surprising patterns of gene flow and differentiation occurring long after the geological changes expected to drive those patterns.
- The study indicates that these fish adapted by dispersing across mountains and were heavily impacted by both climate cycles and human activities, emphasizing the need for thoughtful conservation strategies based on these findings.
Primordial follicle activation (PFA) is a pivotal event in female reproductive biology, coordinating the transition from quiescent to growing follicles. This study employed comprehensive single-cell RNA sequencing to gain insights into the detailed regulatory mechanisms governing the synchronized dormancy and activation between granulosa cells (GCs) and oocytes with the progression of the PFA process. Wntless (Wls) conditional knockout (cKO) mice served as a unique model, suppressing the transition from pre-GCs to GCs, and disrupting somatic cell-derived WNT signaling in the ovary.
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- - The study focuses on the akame fish (Lates japonicus), which has survived for thousands of years despite having a very low genetic diversity, with a heterozygosity rate among the lowest in teleost fishes at 3.3 to 3.4 × 10^-4/bp.
- - Analysis showed that although the akame's effective population size has remained around 1,000 for the last 30,000 years, certain genomic regions related to immunity and sensory systems maintained higher genetic variations, suggesting a balancing selection that helps sustain its viability.
- - Signs of positive selection in akame genes indicate adaptive evolution to its temperate habitat, highlighting that this functional genetic diversity has played a crucial role in the species