Publications by authors named "T A Milner"
Background: In the context of transoral robotic surgery (TORS) for oropharyngeal squamous carcinoma (OPSCC), preoperative imaging and intraoperative visualization plays a pivotal role in optimizing resection margins. Prior work has demonstrated the ability of transoral ultrasound (US) in identifying OPSCC margins and vascular structures. This study evaluates the effectiveness of transcervical ultrasound (TUS), as well as other preoperative imaging modalities, in evaluating OPSCC volumes and compares this to post TORS pathological OPSCC volumes.
View Article and Find Full Text PDFEstrogen Receptor Beta Agonist Influences Presynaptic NMDA Receptor Distribution in the Paraventricular Hypothalamic Nucleus Following Hypertension in a Mouse Model of Perimenopause.
Biology (Basel)
October 2024
Article Synopsis
- - Women can develop hypertension during the transition to menopause, with animal studies showing this condition linked to changes in NMDA receptors in the brain region responsible for regulating blood pressure.
- - Using an accelerated ovarian failure model, researchers discovered that hypertensive peri-menopausal female mice had higher levels of a crucial NMDA receptor subunit (GluN1) in the cytoplasm compared to male mice.
- - Activation of estrogen receptor beta (ERß) in peri-menopausal females not only diminished hypertension but also increased the presence of GluN1 in the cell membranes, unlike in male mice where ERß activation had no effect on blood pressure or GluN1 levels.
Background: This study assesses the feasibility of real-time surgical navigation to plan and guide sequential steps during mandible reconstruction on a series of cadaveric specimens.
Methods: An image-guided surgical (IGS) system was designed including customized mandible and fibula fixation devices with navigation reference frames and an accompanied image-guided software. The mandibular and fibular segmental osteotomies were performed using the IGS in all five cadaveric patients.
infection disparities among Hispanics and non-Hispanics in Yuma, Arizona.
Antimicrob Steward Healthc Epidemiol
September 2024
infection patterns in Yuma, Arizona show a 2.25x higher infection rate in non-Hispanics. Males had higher infection rates in most age classes.
View Article and Find Full Text PDFThere is evidence that tumor necrosis factor alpha (TNFα) influences autonomic processes coordinated within the hypothalamic paraventricular nucleus (PVN), however, the signaling mechanisms subserving TNFα's actions in this brain area are unclear. In non-neuronal cell types, TNFα has been shown to play an important role in canonical NADPH oxidase (NOX2)-mediated production of reactive oxygen species (ROS), molecules also known to be critically involved in hypertension. However, little is known about the role of TNFα in NOX2-dependent ROS production in the PVN within the context of hypertension.
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