Publications by authors named "T A Mattioli"
This article explores the potential of social media in disseminating and communicating archaeological knowledge and the ways in which their impact on the public can be enhanced through marketing plans. It examines the implementation of such a plan in the context of the Facebook page of the ERC Advanced Grant project "The sound of special places: exploring rock art soundscapes and the sacred" (acronym: Artsoundscapes). Using quantitative and qualitative data provided by the Facebook Insights altmetrics tool, the article evaluates the general performance of the Artsoundscapes page and measures the effectiveness of the marketing plan.
View Article and Find Full Text PDFArticle Synopsis
- Benzodiazepines (BZDs) can lead to decreased saliva production by affecting the structure of parotid glands, resulting in changes in cell types like acinar, ductal, and myoepithelial cells.
- The study involved 90 male Wistar rats, with different groups receiving varying treatments of BZDs or pilocarpine over 30 to 60 days to observe effects on cell expression.
- Results indicated that lorazepam increased calponin expression in myoepithelial cells, while midazolam combined with pilocarpine enhanced cell proliferation but reduced calponin levels, suggesting that myoepithelial cells might be particularly affected by BZDs.
The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4). Here, we examined the contribution of TLR4 in the development of morphine tolerance, hyperalgesia, and physical dependence in two inbred mouse strains: C3H/HeJ mice which have a dominant negative point mutation in the Tlr4 gene rendering the receptor non-functional, and B10ScNJ mice which are TLR4 null mutants. We found that neither acute antinociceptive response to a single dose of morphine, nor the development of analgesic tolerance to repeated morphine treatment, was affected by TLR4 genotype.
View Article and Find Full Text PDFA major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K(+)-Cl(-) co-transporter KCC2, impairing Cl(-) homeostasis in rat spinal lamina l neurons. Restoring the anion equilibrium potential reversed the morphine-induced hyperalgesia without affecting tolerance.
View Article and Find Full Text PDFObjective: To study the treatment of fractures of the mandibular condyle and discuss conservative versus surgical therapy.
Methods: We examined the medical records of 892 bucofacial traumas, from which we selected only those who had: reports of condylar fractures, isolated or associated with other facial bones, identification data, dental care history and treatment applied for the condylar fracture. Data were analyzed using descriptive statistics, and the conservative and surgical therapies were compared.