Publications by authors named "T A Leĭnsoo"
Article Synopsis
- The nascent polypeptide-associated complex (NAC) is a crucial ribosome-associated protein involved in protein folding and sorting, and it is conserved across eukaryotic organisms.
- Researchers have identified germline-specific NACαβ paralogs (gNACs), which have unique protein structures in their α and β subunits, particularly longer regions that may be phosphorylated.
- The study suggests that these gNACs play a role in the coordination of protein regulation within germline cells, and there appears to be an interaction between gNACs and the commonly expressed NAC subunits that impacts organismal development.
Article Synopsis
- The nucleolus is not just for ribosome biogenesis; it houses proteins that help regulate the cell cycle and stress responses, including the piRNA binding protein Piwi, which silences transposable elements in Drosophila gonads.
- Research on ovarian somatic cells showed that Piwi's location shifts between the nucleoplasm and the nucleolus, with its retention in the nucleolus linked to specific nucleolar transcripts.
- Stress, particularly heat shock, prompts Piwi to relocate to the nucleolus, suggesting that certain transcripts produced during stress help sequester proteins, impacting the silencing of retrotransposon-containing rDNA copies.
Purpose of the investigation was to examine structural rearrangements in the cortical cytoskeleton as a result of changes in external mechanic conditions. Objects of the investigation were Wistar rat's m. soleus fibers and left ventricle hystiocytes.
View Article and Find Full Text PDFUnlabelled: The main hypothesis suggested that changes in the external mechanical load would lead to different deformations of the submembranous cytoskeleton and, as a result, dissociation of different proteins from its structure (induced by increased/decreased mechanical stress). The study subjects were fibers of the soleus muscle and cardiomyocytes of Wistar rats. Changes in external mechanical conditions were reconstructed by means of antiorthostatic suspension of the animals by their tails for 6, 12, 18, 24 and 72 hours.
View Article and Find Full Text PDFIt has been shown that, after prolonged disuse, the accumulation of muscle mass and the recovery of soleus fibers volume are caused by water accumulation rather than protein synthesis intensification. At the same time, expression rate of the main markers of the activity of ubiquitin-proteasome system remained increased on the 3rd day of reloading and decreased to the control by the 7th day. Both the quantity of the insulin-like growth factor 1 and the number of satellite cells fused with muscle fibers and of myonuclei began to increase only on the 7th day of reloading.
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