Publications by authors named "T A Koski"
Article Synopsis
- * A literature review investigates genetic and pathogenic factors contributing to both idiopathic and adult degenerative scoliosis, examining their complex origins and mechanisms through data sourced from PubMed and Google Scholar.
- * The research categorizes genetic influences on idiopathic scoliosis and identifies factors like inflammation and hormonal changes in adult degenerative scoliosis, while also outlining current research limitations and suggesting future study directions.
Article Synopsis
- - The study is a secondary data analysis of an NIH-sponsored research focusing on cost-effectiveness between surgical and non-surgical treatments for Adult Symptomatic Lumbar Scoliosis (ASLS) eight years post-enrollment.
- - Previous analyses at the five-year mark showed a cost-effectiveness ratio (ICER) of $44,033 (As-Treated) and $27,480 (Intent-to-treat), while the current eight-year data suggests that surgical treatment is more economically favorable, with an ICER of $20,569 per Quality Adjusted Life Year (QALY) gained.
- - The conclusion highlights that operative treatment for ASLS presents a more cost-effective option compared to non-operative treatment, as indicated
Objective: Postural abnormalities are a debilitating symptom of Parkinson disease (PD) that may require spinal intervention. Camptocormia is a unique abnormality most seen in PD, defined by a severe forward flexion of the trunk that completely resolves when supine. The condition presents a challenge due to an undefined pathophysiology and optimal therapeutic approach in a high-risk patient population.
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- Endophytes play a crucial role in plant-insect interactions, yet their specific contributions to managing Emerald Ash Borer (EAB) infestations are not well understood.
- Utilizing advanced genetic analysis methods, the study compares the endophytic fungi and bacteria in the phloem of EAB-infested and healthy samples, revealing significant shifts in community structure and diversity due to infestation.
- The results indicate that while fungal diversity declines and shifts significantly, bacterial abundance increases without diversity change, highlighting complex interactions that could inform better pest control strategies.
Article Synopsis
- Emerald ash borer (EAB) is an invasive pest severely affecting ash trees in North America and Europe, with native ash species showing resistance due to unknown mechanisms.
- A study compared the phloem mycobiomes and metabolites of native and nonnative ash species, finding significant differences in mycobiome communities but no impact from EAB infestation.
- The research highlights a complex relationship between tree chemistry and mycobiomes, suggesting that the co-evolution of native trees and EAB plays a role in their interactions.