Publications by authors named "T A Khokhlova"
Histotripsy-induced bactericidal activity correlates to size of cavitation cloud in vitro.
IEEE Trans Ultrason Ferroelectr Freq Control
October 2024
Article Synopsis
- * Researchers aim to use therapeutic ultrasound, specifically a technique called histotripsy, as a noninvasive way to destroy bacteria within these abscesses.
- * The study found a strong link between the size of the cavitation cloud produced during histotripsy and the effectiveness of bacterial inactivation, indicating promising potential for this ultrasound method.
Pulsed high-intensity focused ultrasound (pHIFU) has the capability to induce de novo cavitation bubbles, offering potential applications for enhancing drug delivery and modulating tissue microenvironments. However, imaging and monitoring these cavitation bubbles during the treatment presents a challenge due to their transient nature immediately following pHIFU pulses. A planewave bubble Doppler technique demonstrated its potential, yet this Doppler technique used conventional clutter filter that was originally designed for blood flow imaging.
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- The study explores boiling histotripsy (BH) for non-invasive kidney tumor ablation, focusing on different BH dose metrics in porcine and canine kidney models.
- Various pulsing protocols were tested to assess lesion formation, revealing that in vivo kidney tissue required lower BH doses compared to ex vivo tissue for similar damage.
- Results indicated tissue stiffness and damage differed between kidney compartments, with the renal cortex needing fewer pulses for effective treatment, while the medulla and renal sinus showed higher resistance to BH dosing.
Dynamic Mode Decomposition for Transient Cavitation Bubbles Imaging in Pulsed High-Intensity Focused Ultrasound Therapy.
IEEE Trans Ultrason Ferroelectr Freq Control
May 2024
Pulsed high-intensity focused ultrasound (pHIFU) can induce sparse de novo inertial cavitation without the introduction of exogenous contrast agents, promoting mild mechanical disruption in targeted tissue. Because the bubbles are small and rapidly dissolve after each HIFU pulse, mapping transient bubbles and obtaining real-time quantitative metrics correlated with tissue damage are challenging. Prior work introduced Bubble Doppler, an ultrafast power Doppler imaging method as a sensitive means to map cavitation bubbles.
View Article and Find Full Text PDFObjective: Tissue susceptibility to histotripsy disintegration has been reported to depend on its elastic properties. This work was aimed at investigation of histotripsy efficiency for liquefaction of human hematomas, depending on their stiffness and degree of retraction over time (0-10 d).
Methods: As an in vitro hematoma model, anticoagulated human blood samples (200 mL) were recalcified at different temperatures.