Publications by authors named "T A Kellogg"
The role of microbes and their metabolites in modulating tuft cell (TC) dynamics in the large intestine and the relevance of this pathway to infections is unknown. Here, we uncover that microbiome-driven colonic TC hyperplasia protects against Clostridioides difficile infection. Using selective antibiotics, we demonstrate increased type 2 cytokines and TC hyperplasia in the colon but not in the ileum.
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- * The new web-based tool, -TIPS, simplifies the genotyping process from Sanger sequencing data by detecting and analyzing the (TG)T tract effectively, providing a user-friendly interface.
- * In tests with clinical samples, -TIPS demonstrated an impressive 99.8% accuracy compared to traditional methods and offers a quick analysis time of under 10 seconds per sample, making it a valuable resource for CFTR genotyping.
Article Synopsis
- HIV is a significant global health issue, particularly in Mozambique, where in 2019 only 95,080 out of an estimated 150,000 infected children received antiretroviral treatment, with only 73% achieving viral suppression.
- A study analyzed the viral load data of 33,559 children aged 0-14 to identify factors linked to achieving viral suppression, defining it as having less than 1,000 copies/ml of blood.
- Results indicated that older age groups (5-14 years) and living in Maputo City were positively associated with viral suppression, whereas being male and living in certain provinces like Niassa and Cabo Delgado were linked to lower rates of suppression.
Inhibition of EZH2 Reduces Aging-Related Decline in Interstitial Cells of Cajal of the Mouse Stomach.
Cell Mol Gastroenterol Hepatol
September 2024
Background & Aims: Restricted gastric motor functions contribute to aging-associated undernutrition, sarcopenia, and frailty. We previously identified a decline in interstitial cells of Cajal (ICC; gastrointestinal pacemaker and neuromodulator cells) and their stem cells (ICC-SC) as a key factor of gastric aging. Altered functionality of the histone methyltransferase enhancer of zeste homolog 2 (EZH2) is central to organismal aging.
View Article and Find Full Text PDFGastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with idiopathic gastroparesis (IG). Single cell sequencing was performed on 26,000 CD45 cells obtained from the gastric tissue of 20 subjects.
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