Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review.

Purpose Of Review: This paper reviewed the current literature on incidence, clinical manifestations, and risk factors of Chimeric Antigen Receptor T-cell (CAR-T) cardiotoxicity.

Recent Findings: CAR-T therapy has emerged as a groundbreaking treatment for hematological malignancies since FDA approval in 2017. CAR-T therapy is however associated with a few side effects, among which cardiotoxicity is of significant concern.

Multidimensional profiles of adolescent social-ecological risk and protective factors and young adult sexual behavior.

Research has demonstrated that social-ecological risk and protective factors at multiple levels are associated with sexual behavior in adolescence. However, relatively little is known about how different patterns of these factors may work together in combination to influence sexual risk. In this study, we use nationally representative data from the U.

The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team-based approach to clinically validated, research-ready electronic health record data.

Introduction: The rapid adoption of electronic health record (EHR) systems has resulted in extensive archives of data relevant to clinical research, hospital operations, and the development of learning health systems. However, EHR data are not frequently available, cleaned, standardized, validated, and ready for use by stakeholders. We describe an in-progress effort to overcome these challenges with cooperative, systematic data extraction and validation.

Virulent and multidrug-resistant Aeromonas in aquatic environments of Kerala, India: potential risks to fish and humans.

Aeromonas inhabit diverse aquatic habitats and are recognized as both opportunistic and primary pathogens of fish and humans. This study delineates the biochemical and gyrB sequence-based molecular identification of 14 Aeromonas strains isolated from aquatic environments in Kerala, India, identifying them as A. dhakensis (50%), A.