[Laboratory and clinical study of therapeutic efficacy of medicinal films for surgical procedures].

An analysis of the experimental data showed that anesthetic medicinal films (AMFs) offer an effective medicinal form for the treatment of suppurative inflammatory disorders(SIDs) of soft tissues. The results of preclinical experiments with AMFs showed evidence of anesthetic, antimicrobial, and hemostatic effects. The therapeutic effect was established in the course of clinical investigations and confirmed by the results of cytological, histological, morphological, and bacteriological testing.

[Lymphocytes as markers of etiologic and pathogenetic factors of infectious diseases].

In the examination of patients with the dermato-respiratory syndrome, peptic ulcer, pyoderma and surgical wounds for their immune status for the expression of receptors of immunocytokins (interferon, interleukin-2), autocoids (histamine, serotonin), neuromediators (acetylcholine, dopamine, epinephrine, norepinephrine) and for the presence of Staphylococcus aureus and Helicobacter pylori antigens have revealed that lymphocytes are the markers of the presence of infection in the body, pathogenetic systemic and intersystemic disturbances, adequately chosen therapy and its effectiveness.

[The immunomodulating activity of a transfer-factor preparation transflavin, specific to tick-borne encephalitis virus].

Transflavin, a transfer-factor preparation specific to tick-borne encephalitis virus, was experimentally shown to possess immunomodulating action. The immunomodulating action of this preparation could be observed in a dose of 1 D (1 D being equivalent to 5 x 10(8) lymphocytes), which was manifested by an increase in the phagocytic activity of neutrophils and macrophages, a rise in the amount of T-lymphocytes, an increase in rosette formation, the number of antibody-forming cells, increased proliferation on T- and, to a lesser extent, B-cell mitogens, the restoration of the T-dependent expression of lymphocyte receptors, inhibited by trypsin. Transflavin in doses of 0, 1 and 10 D suppressed primary immune response.

[The character of development of the immune response to sheep erythrocytes and parallel responses to exo- and endobiotics].

The immune response to sheep erythrocytes (SE) is usually used as the indicator system in screening of immunotropic compounds. We had shown earlier that a rapid immune reaction develops in response to a chemical compound (drug). It is characterized by an increase in the number of antigen-recognizing and antigen-producing lymphocytes and their blast forms, titers of antibodies specific of the introduced compound and endobiotics mobilized under its effect.

[Effectiveness of peroral application of a new immunocorrective agent of natural origin].

Data on peroral application of new peptide origin immunocorrector from nervous tissue of hydrobionts are cited. It has been established that immunological gangliin activity, perorally introduced, is close to that being applied parenterally. This drug comprises a soft immunocorrector that is expressed by humoral and cellular factor strengthening of immunity, increasing induces of phagocynosis of PMNC and sells SMPh.