[The diagnostic and therapeutic significance of thrombocyte functional activity and the factors in its regulation in chronic diseases of the large intestine].

To elucidate diagnostic value of platelet functional activity in chronic colon disease, we studied ADP-induced platelet aggregation (PA, in vitro) and cAMP concentration in blood plasma. If patients had chronic catarrhal, ulcerative colitis or chronic colon stasis, their serum cAMP appeared low, while initial rate of ADP-induced PA was high. The above alterations varied with the disease severity, in exacerbation and remission.

[The functional activity of the thrombocytes in chronic diseases of the large intestine].

Chronic diseases of the large intestine--catarrhal colitis, colonic stasis, unspecific ulcerative colitis, and amebiasis of the large intestine are attended by marked changes in the functional activity of blood platelets and factors of its regulation. They reflect the dynamics of the disease before and after operative and nonoperative treatment. A recurrence of the disease is linked with activation of blood platelets.

[Plasma histamine levels in various chronic diseases of the colon].

Patients suffering from chronic colitis, chronic stasis disease and nonspecific ulcerous colitis were examined for blood plasma histamine. The level of blood plasma histamine was found to be dependent on the intensity of the pathological process. The role of histamine in the development of disorders of neurohumoral regulation, microcirculation and motor and evacuatory function of the colon is discussed.