Publications by authors named "T A Hagan"
We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity.
View Article and Find Full Text PDFWe report on discovering the homogeneous boiling within a liquid film residual resting in equilibrium over a melting ice block. This phenomenon was induced via longwave infrared radiation generated by a continuous wave [Formula: see text] laser. This investigation employed a high-speed camera and the Schlieren visualization technique.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes the formation of contrails from ammonia-powered engines compared to traditional jet fuel engines, focusing on thermodynamic processes like supersaturation and ice nucleation.
- It calculates how moisture from exhaust affects atmospheric conditions, determining the potential for contrail visibility based on temperature and humidity changes.
- Findings suggest that ammonia contrails are less dense but can form at lower altitudes and last longer due to higher moisture content, despite not producing soot which typically aids contrail formation.
The prevalence of depression and anxiety in patients with metastatic disease to the spine.
J Craniovertebr Junction Spine
September 2024
Article Synopsis
- The study highlights that about 20% of patients with metastatic spine disease experience depression, while approximately 17% struggle with anxiety, emphasizing the need for mental health awareness in this population.
- Data was collected from patients over 18 years old who underwent treatment for metastatic spinal disease from 2017 to 2022, revealing a significant number of both depression and anxiety diagnoses among them.
- The findings suggest that spine surgeons should actively screen for mental health issues in patients with spinal metastases to ensure timely referrals for psychological support.
Article Synopsis
- The study examines how the adjuvant AS03 affects vaccination responses in humans receiving the H5N1 influenza vaccine by analyzing data over 14 time points, including the immediate aftermath of the vaccination.
- Researchers developed a computational method to identify complex immune response patterns, revealing differences in how the immune system responds to the vaccine with and without the adjuvant at different stages of vaccination (prime and boost).
- Findings indicate that certain immune response signatures persist long after vaccination, and specific immune cell characteristics, particularly in monocytes and CD8 T cells, are associated with stronger antibody responses, suggesting that pre-existing immune states can influence vaccine effectiveness.