Direct Oral Anticoagulants Versus Warfarin in Patients With Isolated Heparin-Induced Thrombocytopenia or Heparin-Induced Thrombocytopenia With Thrombosis.

No existing studies compare oral anticoagulants to treat heparin-induced thrombocytopenia with or without thrombosis (HIT/HITT). This retrospective study evaluated thrombotic and bleeding outcomes in adults treated for HIT/HITT with a direct oral anticoagulant (DOAC) or warfarin between 2012 and 2023 within the Ochsner Health System. Patients with mechanical heart valves, valvular atrial fibrillation, antiphospholipid syndrome, active malignancy, or venous thromboembolism (VTE) within the previous 6 months were excluded.

[The environmental impact of digital technology and artificial intelligence, in the era of digital pathology].

While digitization and artificial intelligence represent the future of our specialty, future is also constrained by global warming and overstepping of planetary limits, threatening human health and the functioning of the healthcare system. The report by the Délégation ministérielle du numérique en santé and the French government's ecological planning of the healthcare system confirm the need to control the environmental impact of digital technology. Indeed, despite the promises of dematerialization, digital technology is a very material industry, generating greenhouse gas emissions, problematic consumption of water and mineral resources, and social impacts.

Obesity and Psychiatric Disorders.

Many psychiatric disorders are associated with obesity and include mood disorders, anxiety disorders, personality disorders, attention deficit hyperactivity disorder, binge eating disorders, trauma, bipolar disorder, and schizophrenia. According to National Obesity Observatory, there is evidence that both obesity and mental health disorders take up a significant portion of the global burden of disease. The bidirectional nature of obesity and mental illness indicates the importance of screening all persons being treated for either obesity or mental illnesses be screened for the other.

Hematogones With Lambda Light Chain Restriction in a 4-Year-Old Boy With Burkitt Lymphoma: A Potential Diagnostic Pitfall.

Hematogones are immature normal B cell precursors with a characteristic immunophenotype profile on flow cytometry that typically do not express surface immunoglobulin light chains. In this report, we describe a case in which the hematogones exhibit light chain restriction. Our patient was a 4-year-old boy with a complicated medical history involving treatment for a presumed bilateral Wilms tumor of the kidney that on later resection was diagnosed as Burkitt lymphoma.

A new solid-phase support for oligonucleotide synthesis.

An alternative solid support for oligonucleotide synthesis was developed by coupling a polymer colloid to a modified polyethylene filter disc. The functions on the polymer colloid not used for attachment to the surface were derivatized with a Jeffamine diamine and loaded with appropriate deoxynucleoside succinates. The performance of this support system was evaluated and compared to existing resins.