[Widening of possibilities of treatment of multiple sclerosis with the novel oral drug teriflunomide (aubagio)].

Teriflunomide is a novel oral medication for relapsing remitting multiple sclerosis (RRMS), which has demonstrated it's efficacy in relapse rate reduction. It's efficacy has been confirmed by MRI results as well. It is safe and well-tolerated, with mild and transitory side effects.

[Alemtuzumab is a new drug based on monoclonal antibodies for treatment multiple sclerosis: treatment possibilities and risks(review)].

Recently published results of II and II phase clinical trials of alemtuzumab in relapsing-remitting multiple sclerosis (MS) are reviewed. This drug has an immunosuppressive mechanism of action with an anti-inflammatory effect higher than that of high-dose beta-interferon. Its neuroprotective activity and possible side-effects are discussed.

[Changes and patterns of drug resistance of mycobacterium tuberculosis in patients with pulmonary tuberculosis (by data of the microbiological laboratory of research production association "Phthysiology")].

Changes in and patterns of drug resistance of Mycobacterium tuberculosis were analyzed in Yakutia. It was shown that in the past 5 years, there had been no rise in the total resistance; however, its patterns changed: a proportion of polyresistant strains had increased with decreases in monoresistant strains. The rate of Mycobacterium tuberculosis resistance to most antituberculous drugs was found to be growing.

[Characteristics of bacterial excretion in pulmonary tuberculosis patients residents of the Yakut region].

The present state of bacilli excretion in the Yakut area and its certain social aspects are characterized, the detection rate of M. tuberculosis in pulmonary tuberculosis and the sex-age structure are subjected to analysis. Data on the primary and secondary drug resistance, type appertainance of the causative agent and the result of a disinfectant work in the infection foci have been studied in 511 patients having copious bacilli excretion.

[Age changes in the level of pyridinoline cross-linking and ratio of soluble and insoluble collagen in human rib collagen].

The changes in the content of mature crosslinks with pyridinoline structure and soluble/insoluble collagen ratio in the costal cartilage tissue of human beings aged from 1 month to 57 years were found to be age-dependent. The effect of the pyridinoline crosslink content on the soluble/insoluble collagen ratio in human costal cartilage tissue may constitute no less than 67% of the total influence of the sum of all factors. The pronounced nonlinearity of the studied dependencies points to a possible involvement of a factor(s) other than the pyridinoline crosslink content.