Publications by authors named "T A Goncharova"
Article Synopsis
- * The patient initially presented with symptoms like eyelid swelling and redness, which were frequently misidentified as preseptal cellulitis; however, specific ultrasound findings indicated posterior scleritis.
- * Treatment involved corticosteroids and the IL-6 inhibitor tocilizumab, emphasizing the need for a careful and comprehensive diagnosis, as posterior scleritis can be linked to systemic diseases in about 34% of cases.
Background: The finding of mutations that activate epidermal growth factor receptor (EGFR) in people with lung adenocarcinoma resulted in the creation of a new class of biological treatments called tyrosine kinase inhibitors (TKI). These medications have changed how patients with EGFR mutations are clinically managed, nearly doubling their survival rate compared to standard chemotherapy. Though 1st and 2nd generation EGFR TKIs are initially highly effective, typically within 9-14 months all tumors with the mutation progress due to secondary resistance mutations involving alternative molecular pathways.
View Article and Find Full Text PDFPurpureocillium lilacinum-related endophthalmitis: case report.
J Ophthalmic Inflamm Infect
June 2024
Purpose: To report a case of Purpureocillium lilacinum endophthalmitis.
Methods: The case of a fungal endophthalmitis caused by Purpureocillium lilacinum documented in an immunocompetent patient with no apparent trigger.
Results: A 64-year-old male with a two-month history of panuveitis in his left eye was referred to our hospital.
Characteristic Mutational Damages in Gastric and Colorectal Adenocarcinomas.
Asian Pac J Cancer Prev
November 2023
Introduction: Gastric and colorectal adenocarcinomas are prevalent malignancies characterized by mutations in genes such as p53, RAS, and MDM2, which play crucial roles in tumorigenesis and cancer progression. Understanding the specific mutational patterns and their implications in these cancers was essential for identifying potential therapeutic targets.
Aim: To identify the nature of mutational disorders in the p53, p21Waf1, RAS and MDM2 genes, depending on the degree of cell differentiation by adenocarcinomas of the gastrointestinal tract.