Asbestos exposure and tuberculous pleurisy as developmental causes of progressive unilateral upper-lung field pulmonary fibrosis radiologically consistent with pleuroparenchymal fibroelastosis.

Background: Unilateral upper-lung field pulmonary fibrosis (upper-PF), which is radiologically consistent with pleuroparenchymal fibroelastosis, develops after thoracic surgery. In most patients with unilateral upper-PF, aberrant intra-/extra thoracic air commonly emerges and an autopsy shows chronic pleuritis, which indicates that pleural involvement is associated with upper-PF development. If so, there may be patients with unilateral upper-PF who have a history of pleural involvement, including tuberculous pleurisy (TP) or asbestos exposure (AE).

[Cephalosporins in the treatment of children with oncohematologic diseases].

Clinical efficacy of 3rd generation cephalosporins i.e. oral cefpodoxime and parenteral ceftriaxone was studied in the treatment of children with oncohematologic pathology.

[Effects of dexamethasone on Ca++-response of bone marrow lymphoblasts in acute leukemia].

The FURA-2/AM fluorescence dye was used to investigate the influence of dexamethasone treatment on the basal and mitogen-mediated levels of free ions of calcium ([Ca++]i) in the lymphoblast cytoplasm from bone marrow of patients suffering acute leukemia. Treatment with dexamethasone in the dose of 2 microM was shown to significantly stimulate the increase of the basal level of [Ca++]i and to inhibit the Ca++ response of cells to concanavalin A (25 micrograms/ml). Inhibition by dexamethasone was more pronounced after 30 min preincubation of lymphoblasts with a glucocorticoid.

[Comparative study of the interaction of purine antagonists with adenosine receptors of bone marrow lymphocytes and lymphoblasts].

In this study we used the radiolabeled selective ligand (3H-NECA) of A2-types purine receptors in order to investigate specific NECA binding with human blood lymphocytes and bone marrow lymphoblasts. Relative affinity of 6-mercaptopurine and azathioprine for purine receptors was determined. One type of high affinity NECA binding sites have been shown on the lymphocytes (Kd = 0.

[Interaction of glucocorticoids with bone marrow lymphoblast receptors in acute leukemia].

Two types of receptor systems for glucocorticoids: membranous and intracellular have been found on lymphoblasts of children with acute lymphoblastic leukemia by means of radioassay. They differed by localization and affinity for different glucocorticoids either. Modern radioassay needs modification because of no attention paying for interaction of hormones with different types of receptor system.