Publications by authors named "T A Dubiley"
Morning chronotypes are associated with healthier metabolic profiles and lifestyles compared to evening chronotypes. However, limited research examined the relationship between chronotype, dietary intake, and metabolic health using accurate measures such as food records. This cross-sectional study aimed to investigate the association between chronotype, dietary intake, and metabolic health markers in a cohort of Ukrainian individuals.
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- A study of heterochronic parabionts (young and old rats sharing blood) found that the old immune system did not rejuvenate, while the young immune system aged prematurely.
- Various hormones and factors in the blood showed no significant changes after the blood exchange, suggesting that forced aging might not affect all bodily systems equally.
- The experiment revealed that the lifespan of young parabionts decreased, while the old ones only showed a slight, non-significant increase, indicating that components in old blood could contribute to aging in younger organisms.
Several studies claimed C fullerenes as a prospective geroprotector drug due to their ability to capture free radicals effectively and caused a profound interest in C in life extension communities. Multiple additives are already sold for human consumption despite a small body of evidence supporting the beneficial effects of fullerenes on the lifespan. To test the effect of C fullerenes on lifespan and healthspan, we administered C fullerenes dissolved in virgin olive oil orally to 10-12 months old CBA/Ca mice of both genders for 7 months and assessed their survival.
View Article and Find Full Text PDFWe hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not require external sources of gases or complex technical equipment. Here, we showed for the first time that a chronic exposure of mice to HHE could be a unique tool for NMR-like metabolic remodeling, resulting in a long-term and substantial decrease in metabolic rate, body temperature, and food consumption, without significant changes in expression of stress-related genes.
View Article and Find Full Text PDFThe influence of morphine on the life span of Drosophila melanogaster fruit flies has been investigated. Morphine hydrochloride (MH) at concentrations of 0.01, 0.
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