Publications by authors named "T A D Santo"
Article Synopsis
- Gene drives are genetic tools created to spread specific modifications through populations, and a new approach has been developed for herpesviruses that uses co-infection of engineered and wild-type viruses.* -
- This research focused on a gene drive targeting human herpes simplex virus 1 (HSV-1), demonstrating its ability to propagate in cell cultures and during infections in mice, particularly affecting neuronal tissues.* -
- The study revealed significant co-infection and recombination rates in HSV-1, suggesting that these gene drives could serve as potential therapies by effectively spreading genetic modifications during viral infections.*
Article Synopsis
- * Using the IDDSI flow test, the researchers quantitatively analyzed foods like porridge, smoothies, and soups prepared by different cooks at two time points (T0 and T1) to note volume changes.
- * Results showed temperature variations affected food flow, with only porridge changing IDDSI levels from 3 to 4 after one hour; different cooking methods also led to inconsistencies in smoothie and porridge texture across days, emphasizing the influence of temperature and cooking technique on food preparation.
Objectives: In addition to harms caused to individuals who smoke, second-hand smoke (SHS or passive smoke) is an important public health issue. We aim to estimate the extent of preventable deaths due to tobacco and SHS exposure in Southeast Asia.
Methods: Data were from the Global Burden of Disease Study 2019.
Article Synopsis
- Anti-HSV therapies currently only suppress the virus and don't eliminate its dormant form in nerve cells, which causes recurring outbreaks.
- A new gene editing method using HSV-specific meganucleases delivered by adeno-associated virus (AAV) can significantly reduce latent HSV DNA in mouse models, achieving over 90% elimination in orofacial infections and up to 97% in genital infections.
- Although the therapy is mostly well-tolerated, some high doses lead to liver toxicity and mild nerve damage; adjustments like using a single AAV serotype and a specific neuron-targeting promoter could enhance safety without losing effectiveness.
Article Synopsis
- Comorbid substance use disorders (SUDs) are common among individuals with opioid use disorder (OUD), leading to worse health outcomes, including increased risk of overdose and death.
- A systematic review and meta-analysis analyzing data from 194 studies with over 77,000 participants revealed that 59.5% have current non-opioid SUDs, while 72.0% have experienced a comorbid SUD at some point in their lives.
- The most prevalent current non-opioid SUDs identified were cocaine (30.5%), alcohol (27.1%), and cannabis (22.7%), highlighting the need for improved access to treatment for these comorbid conditions.