Publications by authors named "T A Bykova"
Article Synopsis
- Haploidentical stem cell transplantation (haplo-SCT) helps children with a genetic problem that affects their bone marrow when they can’t find a matching donor.
- A study looked at 162 patients and found that the best type of T-cell removal, called TCRαβ/CD19 depletion, led to better survival rates and fewer serious side effects.
- Overall, the study shows that haplo-SCT is a safe option and that the TCRαβ/CD19 method could give kids with these conditions a better chance to live without severe complications.
Article Synopsis
- - The study investigates the effectiveness of post-transplant cyclophosphamide (PTCy) in preventing graft-versus-host disease (GVHD) in pediatric acute leukemia patients who underwent matched allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- - A retrospective analysis of 190 children shows that PTCy-based GVHD prophylaxis led to significantly lower rates of acute and chronic GVHD after transplants from matched unrelated donors (MUD) compared to standard treatments.
- - The findings suggest PTCy is a promising and effective option for GVHD prevention in pediatric patients, particularly in MUD settings, while showing similar efficacy to traditional methods in matched sibling donor (MSD) transplants. *
Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience.
Cancers (Basel)
September 2023
Article Synopsis
- This analysis reviewed trends in 5185 hematopoietic cell transplantations (HCT) between 1990 and 2022, including 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) transplants.
- There was a significant improvement in event-free survival (EFS) for both autoHCT and alloHCT over time, attributed to a decrease in relapse rates and non-relapse mortality, respectively.
- Specific survival improvements were noted for various conditions, with autoHCT showing better outcomes in Hodgkin's disease and multiple myeloma, while alloHCT advancements were observed mainly in leukemia and lymphomas.
Composites with a copper matrix attract the attention of researchers due to their ability to combine high ductility, heat conductivity, and electrical conductivity of the matrix with the high hardness and strength of the reinforcing phases. In this paper, we present the results of studying the effect of thermal deformation processing of a Сu-Ti-C-B composite produced by self-propagating high-temperature synthesis (SHS) on its ability to deform plastically without failure. The composite consists of a copper matrix and reinforced particles of titanium carbide TiC (sized up to 1.
View Article and Find Full Text PDFPurpose: Allogeneic hematopoietic stem cell transplantation (HSCT) is an established therapy for many inborn errors of immunity (IEI). The indications for HSCT have expanded over the last decade. The study aimed to collect and analyze the data on HSCT activity in IEI in Russia.
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