Publications by authors named "T A Braunschweig"
Background: An estimated 20% of patients with oral and oropharyngeal squamous cell carcinoma (OOSCC) have micrometastases (Mi) or isolated tumor cells (ITC) in the cervical lymph nodes that evade detection by standard histological evaluation of lymph node sections. Lymph node Mi and ITC could be one reason for regional recurrence after neck dissection. The aim of this study was to review the existing data regarding the impact of Mi on the survival of patients with OOSCC.
View Article and Find Full Text PDFCyto R-CNN and CytoNuke Dataset: Towards reliable whole-cell segmentation in bright-field histological images.
Comput Methods Programs Biomed
July 2024
Background And Objective: Cell segmentation in bright-field histological slides is a crucial topic in medical image analysis. Having access to accurate segmentation allows researchers to examine the relationship between cellular morphology and clinical observations. Unfortunately, most segmentation methods known today are limited to nuclei and cannot segment the cytoplasm.
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- Liposarcomas are a common type of cancer with limited treatment options, and their classification is complicated by varied characteristics and lack of specific markers, making molecular analysis essential.
- A study reclassified archived liposarcoma cases using FISH analysis, revealing that 20 out of 54 cases had significant co-amplification of the HER3 gene alongside MDM2, indicating potential therapeutic targets.
- The findings suggest HER3 could be a promising target for future treatments in liposarcoma, warranting further research into its role in therapy.
Objective: The gold standard of oral cancer (OC) treatment is diagnostic confirmation by biopsy followed by surgical treatment. However, studies have shown that dentists have difficulty performing biopsies, dental students lack knowledge about OC, and surgeons do not always maintain a safe margin during tumor resection. To address this, biopsies and resections could be trained under realistic conditions outside the patient.
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