Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain in Mice.

Deep brain stimulation (DBS) using electrical stimulation of neuronal tissue in the basal forebrain to enhance release of the neurotransmitter acetylcholine is under consideration to improve executive function in patients with dementia. While some small studies indicate a positive response in the clinical setting, the relationship between DBS and acetylcholine pharmacokinetics is incompletely understood. We examined the cortical acetylcholine response to different stimulation parameters of the basal forebrain.

Confinement and Catalysis within Designed Peptide Barrels.

protein design has advanced such that many peptide assemblies and protein structures can be generated predictably and quickly. The drive now is to bring functions to these structures, for example, small-molecule binding and catalysis. The formidable challenge of binding and orienting multiple small molecules to direct chemistry is particularly important for paving the way to new functionalities.

Improved Diet Quality in Elite and Entry-Level Military Women Compared With Civilian-Matched Counterparts.

Background: Dietary intake is a modifiable factor linked to short-term and long-term health. The Healthy Eating Index (HEI) is an objective measure to assess diet quality and population-level comparisons, like military to civilian.

Objectives: This study aimed to characterize diet quality of early-career and mid-career female soldiers compared with that of age-matches and sex-matched civilians and to link indicators of cardiometabolic disease risk to dietary outcomes and health status.

Exploring the Link Between Obligate Anaerobe-Related Dysbiosis and Prostate Cancer Development: A Pilot Study.

Background/objectives: Several independent studies have associated prostate cancer (PCa) with specific groups of bacteria, most of them reporting the presence of anaerobic or microaerophilic species such as (). Such findings suggest a prostate cancer-related bacterial dysbiosis, in a manner similar to the association between infection and gastric cancer. In an earlier exploratory study looking for such dysbiosis events, using a culturomics approach, we discovered that the presence of obligate anaerobes (OAs) along with was associated with increased prostate-specific antigen (PSA) levels in 39 participants.

Stress by Design: A Scoping Review of Structural Stress of Emergency Telecommunicators.

Background: Most agree that occupational stress is caused by workplace strains, tensions, and demands that originate from characteristics of the work. The accumulation of multiple types of stress has been found to have calamitous effects on health and well-being. One such occupation, emergency telecommunicators, experiences a multitude of stressors within their day-to-day work environment.