Comorbidity and dementia: A nationwide survey in Taiwan.

Background: Comorbid medical diseases are highly prevalent in the geriatric population, imposing hardship on healthcare services for demented individuals. Dementia also complicates clinical care for other co-existing medical conditions. This study investigated the comorbidities associated with dementia in the elderly population aged 65 years and over in Taiwan.

Induction of intracellular heat-shock protein 72 prevents the development of vascular smooth muscle cell calcification.

Aims: Vascular calcification (VC) is a significant contributor to cardiovascular mortality in patients with chronic kidney disease (CKD) and coronary artery disease (CAD). Osteo/chondrocytic transformation and simultaneous dedifferentiation of smooth muscle cells (SMCs) are important in the pathogenesis of VC. Heat-shock protein 72 (HSP72) is a cardioprotective inducible heat-shock protein that functions as a molecular chaperone.

Interpretation of biological and mechanical variations between the Lowry versus Bradford method for protein quantification.

Background: The identification of differences in protein expression resulting from methodical variations is an essential component to the interpretation of true, biologically significant results.

Aims: We used the Lowry and Bradford methods- two most commonly used methods for protein quantification, to assess whether differential protein expressions are a result of true biological or methodical variations. MATERIAL #ENTITYSTARTX00026;

Methods: Differential protein expression patterns was assessed by western blot following protein quantification by the Lowry and Bradford methods.