Spatheliachromen mitigates methylglyoxal-induced myotube atrophy by activating Nrf2, inhibiting ubiquitin-mediated protein degradation, and restoring mitochondrial function.

Background: Methylglyoxal (MGO) is a potent precursor of glycative stress that leads to oxidative stress and muscle atrophy in diabetes. Spatheliachromen (FPATM-20), derived from Ficus pumila var. awkeotsang, exhibited potential antioxidant activity.

Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions.

Mechanochemical reactions achieved by processes such as milling and grinding are promising alternatives to traditional solution-based chemistry. This approach not only eliminates the need for large amounts of solvents, thereby reducing waste generation, but also finds applications in chemical and materials synthesis. The focus of this study is on the synthesis of quinazolinone derivatives by ball milling, in particular evodiamine and rutaecarpine analogues.

Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3--Tirucallane Triterpenoids Meliadubins A and B from Cav. Barks with ChemGPS-NP and In Silico Prediction.

Two new rearranged 2,3--tirucallane triterpenoids, meliadubins A () and B (), along with four known compounds, -, were isolated from the barks of Cav. Compound exhibited a significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC at 5.54 ± 0.

Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.

The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data.

Lipid Metabolism and its Mechanism Triggered by Supercritical CO Extract of Adlay ( (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters.

Adlay ( (Rom. Caill.) Stapf) seeds are edible crop classified as Traditional Chinese Medicine (TCM).

Ethyl Acetate Extract Provides Oxidative Stress-Dependent Anti-Leukemia Effects.

Several kinds of solvents have been applied to extractions exhibiting antioxidant and anticancer effects. However, they were rarely investigated for ethyl acetate extract (EANT), especially leukemia cells. The purpose of the present study was to evaluate the antioxidant properties and explore the antiproliferation impact and mechanism of EANT in leukemia cells.

Estrogenic and anti-neutrophilic inflammatory phenanthrenes from L.

L. () is a Traditional Chinese Medicine (TCM) that has long been used for dealing with gynaecological disorders, such as relieving insomnia, preventing tinnitus, reducing edema with diuretic effect. In our course of evidence-based medical research focused on this herb, one new phenanthrene, Junfusol B (), together with seventeen known compounds were isolated and identified.

Correction: Ou-Yang, F. et al. Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of x ( x ). 2019, , 3238.

The authors would like to make corrections to their published paper [...

Antiproliferation for Breast Cancer Cells by Ethyl Acetate Extract of x ( x ).

Extracts from the Nepenthes plant have anti-microorganism and anti-inflammation effects. However, the anticancer effect of the Nepenthes plant is rarely reported, especially for breast cancer cells. Here, we evaluate the antitumor effects of the ethyl acetate extract of x ( x ) (EANT) against breast cancer cells.

Components from the Leaves and Twigs of Mangrove with Anti-Angiogenic and Anti-Inflammatory Effects.

One new neolignan, racelactone A (), together with seven known compounds (-) were isolated from the methanolic extract of the leaves and twigs of . The structure of racelactone A () was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation.