Publications by authors named "Szilard Szucs"
Article Synopsis
- Fractured neck of femur (FNF) frequently affects the elderly, and this study explores the effects of using a spinal catheter with local anesthetic bupivacaine and fentanyl for surgery.* -
- A clinical trial assessed the initial minimum local anesthetic dose needed for operations like dynamic hip screw implantation and hemiarthroplasty due to FNF, with results indicating specific dosage thresholds established through statistical methods.* -
- The findings showed that a spinal catheter allows for precise dosing, significantly reducing the required local anesthetic dose for surgery while maintaining effective pain control through the combination of bupivacaine and opioids.*
Article Synopsis
- The study investigates the relationship between exhaled methane (CH4) and changes in splanchnic blood flow to identify intestinal perfusion failure in gastrointestinal disorders.
- The research utilizes an in vivo animal model, specifically anesthetized rats and pigs, to monitor blood flow and CH4 levels during induced mesenteric ischemia and reperfusion scenarios.
- Results indicate a significant correlation between intestinal blood flow changes and CH4 concentration in exhaled breath, suggesting methane breath tests could be used to assess intestinal perfusion issues.*
Objectives: Extracorporeal circulation induces cellular and humoral inflammatory reactions, thus possibly leading to detrimental secondary inflammatory responses. Previous data have demonstrated the bioactive potential of methane and confirmed its anti-inflammatory effects in model experiments. Our goal was to investigate the in vivo consequences of exogenous methane administration on extracorporeal circulation-induced inflammation.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to create a large animal model using Vietnamese mini pigs to simulate pericardial tamponade, a critical condition that affects heart function and blood flow.
- The researchers induced tamponade in one group of pigs by injecting their own blood into the pericardium while monitoring various hemodynamic and circulatory parameters.
- The results showed significant changes in blood flow and increased inflammation in the intestines, indicating that this model effectively replicates the clinical aspects of pericardial tamponade and can be used for further study of cardiogenic shock.
Our aim was to characterize the main components of the nitrosative response with quantitative changes of the nitrergic myenteric neurons in adjacent intestinal segments after transient superior mesenteric artery occlusion. We also tested the hypothesis that exogenous methane may modulate the evolution of nitroxidation by influencing xanthine oxidoreductase (XOR) activity. The microcirculatory consequences of a 50 min ischemia or ischemia-reperfusion were investigated in anesthetized rats (n = 124) inhaling normoxic air with or without 2.
View Article and Find Full Text PDFArticle Synopsis
- Acute pericardial tamponade is a critical condition in cardiac surgery that can cause severe complications like cardiogenic shock and even death.
- Although diagnosing tamponade has become easier with modern methods, managing it effectively and understanding its long-term impacts remain complex challenges.
- The review aims to provide a comprehensive overview of pericardial tamponade, covering its historical significance, underlying mechanisms, and importance in surgical models.
Article Synopsis
- Pericardial tamponade (PT) is a critical condition that reduces blood flow, impacting circulation in vital organs like the kidneys and intestines, prompting researchers to create a large animal model for study.
- Vietnamese minipigs were used in the experiment, with one group undergoing PT induction and a control group for comparison, while monitoring various circulatory parameters and tissue effects during the procedure.
- Results showed PT increased central venous pressure and heart rate, decreased blood flow to the mesentery and kidneys, and caused noticeable tissue damage, highlighting the model's effectiveness for future medical research on PT's effects.
Introduction: Non-occlusive mesenteric ischemia (NOMI) develops without anatomical causes. Early diagnosis is challenging and treatments are of questionable effectiveness. We investigated the role of complement activation in the pathophysiology of NOMI in animal models through the inhibition of complement C5a.
View Article and Find Full Text PDFArticle Synopsis
- A new compound, ASA-Tris, was developed from acetylsalicylic acid and Tris to have similar anti-inflammatory effects to ASA but with less damage to the digestive system.
- In a study on rats with colitis, ASA-Tris and mesalamine treatments reduced inflammation and tissue damage significantly more than ASA alone, which still caused some gastric injury.
- The findings suggest that ASA-Tris is more effective in protecting against colonic injury in inflammatory conditions compared to traditional ASA, making it a promising alternative for treatment.
Article Synopsis
- The study investigates how inhaling exogenous methane affects the intestinal barrier function during acute inflammation in rats after a temporary loss of blood flow to the intestine.
- Results showed that after reperfusion, there was an increase in epithelial permeability and inflammatory responses, but inhaling methane helped maintain mucosal structure, reduce permeability, and enhance microcirculation.
- The findings suggest that using normoxic methane could be a beneficial approach to protect intestinal tissue from damage caused by oxidative stress during ischemia-reperfusion injuries.
Article Synopsis
- A study was conducted to evaluate the effectiveness of preoperative dexamethasone in improving pain management for elderly patients undergoing surgery for fractured neck of femur.
- Patients were randomly assigned to receive either dexamethasone or a placebo before surgery, with pain scores and opioid consumption measured afterward.
- Results showed that those who received dexamethasone reported significantly lower pain levels and used less morphine post-surgery compared to the placebo group.
Article Synopsis
- Nonocclusive mesenteric ischemia (NOMI) is linked to low blood flow and can lead to severe intestinal damage, with potential roles of vasoconstriction and complement activation in its development.
- A study used a rat model to assess the effects of a C5a antagonist (AcPepA) on issues caused by partial aortic occlusion, focusing on blood pressure, microcirculation, and inflammatory markers.
- Results showed that AcPepA treatment improved hemodynamics and microcirculation while reducing inflammation and tissue damage, suggesting its potential for therapeutic use in preventing NOMI-related complications.
Article Synopsis
- Femoral neck fractures often need surgical intervention, with spinal anaesthesia being a common choice among anaesthetists, despite potential severe side effects from single-shot techniques.
- This study aimed to identify the smallest effective dose of 0.5% isobaric bupivacaine given intrathecally to achieve surgical anaesthesia rapidly (within 15 minutes).
- Researchers conducted a trial with 23 patients, finding that the minimum effective dose needed was 0.24 ml, which could guide clinicians in selecting the appropriate dosage for spinal anaesthesia.
Background: Fractured neck of femur generally requires operative fixation and is a common cause of admission to hospital. The combination of femoral nerve block and spinal anesthesia is a common anesthetic technique used to facilitate the surgical procedure. The optimal disposition of local anesthetic (LA) relative the femoral nerve (FN) has not been defined.
View Article and Find Full Text PDFUltrasound guided regional anaesthesia is becoming increasingly popular. The supraclavicular block has been transformed by ultrasound guidance into a potentially safe superficial block. We reviewed the techniques of performing supraclavicular block with special focus on ultrasound guidance.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of continuous femoral nerve block (CFNB) for pain relief in patients with fractured neck of femur (FNF), comparing it to standard opiate-based analgesia.
- Patients were divided into two groups: one receiving morphine as needed (Group 1), and the other receiving CFNB with bupivacaine (Group 2).
- Results showed that Group 2 experienced significantly lower pain scores at rest and during movement for up to 54 hours compared to Group 1, indicating CFNB may be a more effective pain management strategy for this type of injury.
Article Synopsis
- - Thoracic paravertebral blockade is a straightforward technique that can be learned easily and has a low risk of complications.
- - It offers a safe alternative to traditional thoracic epidural analgesia or anesthesia.
- - The review focuses on the methods of performing thoracic paravertebral blockade, particularly emphasizing the use of ultrasound guidance.
Femoral nerve blockade is the most widely performed lower limb block. Methods of femoral nerve blockade are briefly reviewed with particular reference to ultrasound guidance.
View Article and Find Full Text PDF