Selected immunohistochemical markers in stromal neoplasms of the gastrointestinal tract.

We studied immunohistochemical reactions to vimentin, desmin and protein S-100 in 43 cases of stromal tumors of the gastrointestinal tract. The material studied included: 1 esophageal tumor, 18 gastric tumors, 19 small intestinal tumors and 5 colonic tumors, classified in 13 cases as benign and in 30 cases as malignant neoplasms of various degree of malignancy. Mean age of the patients was 58.

Coexpression of vimentin and desmin in gastric leiomyomas. An immunohistochemical study in paraffin sections.

The aim of the study was to evaluate the incidence of the reactions for vimentin and desmin in gastric leiomyomas routinely processed in formalin and embedded i paraffin. The material studied included four benign leiomyomas, seven malignant leiomyomas and three malignant epithelioid leiomyomas. A positive reaction to vimentin was found in 13 out 14 leiomyomas under study.

Morphometry of normal, regenerating and cancerous hepatocytes.

During the morphometric analysis of liver cell carcinomas arising in cirrhotic livers, the sizes and shapes of 2200 cancerous and 1800 regenerative hepatocytes were measured and compared to normal hepatocytes. The neoplastic population showed significantly higher polymorphism, nucleocytoplasmic ratio and the percentage of multinucleated cells, whereas the sizes of cancerous cells were the smallest. Values for regenerative cells were mainly between those of neoplastic and normal cells.

Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat.

We studied whether 16,16--dimethyl prostaglandin E2 (dmPGE2) may prevent acute liver damage induced by carbon tetrachloride (CCl4) in the rat. One hundred thirty male rats were divided into the following groups: (1) controls, (2) rats given CCl4 6670 mg/kg body wt subcutaneously, (3) rats pretreated with 5 micrograms/kg dmPGE2 given subcutaneously 30 min before, and 8 and 24 h after CCl4 administration, and (4) animals given dmPGE2 only as in group 3. Liver damage was assessed by biochemical studies (SGPT, serum alkaline phosphatase, and bilirubin) and by histology.

Cytoprotective effect of 16, 16' dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rat.

Present experiment was aimed to study whether 16, 16' dimethylprostaglandin E2 (dmPGE2), Hepatofalk (HF), or Orotofalk (OF) may prevent an acute liver damage induced in rats with D-galactosamine (GalN). Fifty male rats were divided into 5 groups: 1. controls, 2.

Obstruction of a ureter by isolated primary focal amyloidosis.

A rare case of obstruction of the pelvic segment of the ureter by an isolated focus of primary amyloidosis is described. The operation consisted of resection of the constricted segment of the ureter and end-to-end anastomosis, with very good early and late results. The differential diagnosis and therapy of this type of ureteral obstruction are discussed.

Histochemical and ultrastructural observation of endocrine cells in pathological gastric mucosa.

Recent achievements of gastrointestinal endocrinology on the basis of new techniques enabled investigation of endocrine cells in pathological conditions. The present paper describes investigations of 56 surgical cases of the stomachs operated on for duodenal and gastric ulcer and gastric cancer. Argyrophilic cell hyperplasia was common in non-metaplastic antropyloric mucosa in duodenal ulcer cases, not so common, however, in gastric ulcer and gastric cancer.